Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ndt/gfh593 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Real-World Antifungal Therapy Patterns Across the Continuum of Care in United States Adults with Invasive Aspergillosis.
J Fungi (Basel)
December 2024
School of Pharmacy, University of Connecticut, 69, North Eagleville Road, Storrs, CT 06269, USA.
Changes to antifungal therapy (AFT) in invasive aspergillosis (IA) may occur due to intolerance, side effects, drug interactions, or lack of response. We describe AFT change patterns in IA patients. This was a US claims data study.
View Article and Find Full Text PDFDrug-drug interaction of phenytoin sodium and methylprednisolone on voriconazole: a population pharmacokinetic model in children with thalassemia undergoing allogeneic hematopoietic stem cell transplantation.
Eur J Clin Pharmacol
December 2024
Department of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Purpose: Voriconazole (VRC) is recommended for the prevention and treatment of invasive fungal infections in children undergoing hematopoietic stem cell transplantation (HSCT). It demonstrates nonlinear pharmacokinetics (PK) and exhibits substantial inter- and intraindividual variability. Phenytoin sodium (PHT) and methylprednisolone (MP) are commonly used in the early stages of HSCT to prevent epilepsy and graft-versus-host disease.
View Article and Find Full Text PDFComparative Genomic Analysis of an Strain Isolated from a Patient with Urinary Tract Infection.
Pol J Microbiol
December 2024
Department of Clinical Laboratory, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Opportunistic infections caused by fungi, particularly those occurring in immunocompromised patients, are considered challenging worldwide. Therefore, a comprehensive understanding of pathogenic fungi is necessary. The present study reports the isolation of a strain of , which is difficult to detect using conventional clinical assays, from the sterile urine samples of a patient with a urinary tract infection.
View Article and Find Full Text PDFInfection in Teen With Acute Myeloid Leukemia Receiving Echinocandin Prophylaxis.
Case Rep Infect Dis
November 2024
Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.
We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.
View Article and Find Full Text PDFEffect of inflammation on voriconazole levels in patients with invasive pulmonary aspergillosis.
J Infect Dev Ctries
October 2024
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Article Synopsis
- Voriconazole (VCZ) serum concentrations can be influenced by various factors, and this study explores its levels in patients with COVID-19-associated aspergillosis (CAPA) and invasive pulmonary aspergillosis (IPA).
- The study included 85 patients, finding that about 50.6% had VCZ levels in the therapeutic range, while a significant number had either sub-therapeutic or supra-therapeutic levels, with inflammation markers notably higher in those with supra-therapeutic levels.
- CAPA patients showed a higher incidence of adverse effects and elevated VCZ levels compared to IPA patients, highlighting the need for more frequent monitoring of VCZ in this group.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!