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"Caution with choroidals" - choose the right one at right time.
Indian J Ophthalmol
December 2024
Department of Oculoplasty, Disha Eye Hospitals Pvt Ltd, Kolkata, West Bengal, India.
Article Synopsis
- Choroidal detachment (CD) during retinal detachment surgery can negatively affect surgical results and vision, necessitating specific management techniques.
- Cannula-guided choroidal drainage is essential for mitigating pre-existing CDs, especially in complex cases with hemorrhagic detachment.
- Intraoperative sudden CD can be caused by issues like hypotony or air entry from cannula slippage, which may lead to serious complications like Venous Air Embolism (VAE); prompt action to stop air infusion is critical to prevent life-threatening outcomes.
Impact of Social Restrictions During COVID-19 on the Aquatic Levels of Antimicrobials and Other Drugs in Delhi.
Cureus
May 2024
High-Precision Bioanalytical Facility (DST-FIST sponsored) Ocular Pharmacology and Pharmacy Division, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
The relative contribution of factors responsible for the environmental exposure of active pharmaceutical ingredients (APIs) is of interest for appropriate remedial measures. This study was carried out to evaluate the post-lockdown levels of APIs in water resources, in comparison to our previously published study from 2016. The environmental levels of 28 drugs from different classes were analyzed in surface water (Yamuna River), aquifers, and leachate samples collected from 26 locations in Delhi-NCR using the previously validated liquid chromatography-mass spectrometry (LC-MS/MS) methods.
View Article and Find Full Text PDFA digoxin derivative that potently reduces intraocular pressure: efficacy and mechanism of action in different animal models.
Am J Physiol Cell Physiol
May 2024
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Glaucoma is a blinding disease. Reduction of intraocular pressure (IOP) is the mainstay of treatment, but current drugs show side effects or become progressively ineffective, highlighting the need for novel compounds. We have synthesized a family of perhydro-1,4-oxazepine derivatives of digoxin, the selective inhibitor of Na,K-ATPase.
View Article and Find Full Text PDFRole of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction.
Hum Cell
March 2024
Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
Glaucoma is one of the leading causes of irreversible blindness in developed countries, and intraocular pressure (IOP) is primary and only treatable risk factor, suggesting that to a significant extent, glaucoma is a disease of IOP disorder and pathological mechanotransduction. IOP-lowering ways are limited to decreaseing aqueous humour (AH) production or increasing the uveoscleral outflow pathway. Still, therapeutic approaches have been lacking to control IOP by enhancing the trabecular meshwork (TM) pathway.
View Article and Find Full Text PDFKnockdown of lncRNA PVT1 protects human trabecular meshwork cells against HO-induced injury the regulation of the miR-29a-3p/VEGF/MMP-2 axis.
Heliyon
January 2024
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Purpose: Human trabecular meshwork cell (HTMC) dysfunction results in imbalanced aqueous humor inflow and outflow, leading to an increase in intraocular pressure (IOP). Uncontrolled high IOP can promote the occurrence of glaucoma, an irreversible optic neuropathy. Here, we explored whether the long non-coding RNA plasmacytoma variant translocation 1 (lncRNA PVT1)/microRNA-29a-3p (miR-29a-3p) axis could ameliorate HTMC dysfunction under oxidative stress by modulating the expression of the proangiogenic factor vascular endothelial growth factor (VEGFA) and the profibrotic factor metalloproteinase-2 (MMP-2).
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