AI Article Synopsis
- The study investigates how short-term hypertension affects Oscillatory Potentials (OPs) in Electroretinogram (ERG) readings and their connection to ocular perfusion pressure (OPP).
- Results showed that changes in OPP significantly impacted scotopic OPs more than photopic OPs, with reductions ranging from 21% to 47% for scotopic and 14% to 34% for photopic conditions.
- The findings suggest that OPs can indicate alterations in OPP and highlight the role of retinal autoregulation, paving the way for further clinical research.
Article Abstract
Purpose: To evaluate the changes of the Oscillatory Potentials (OPs) of Electroretinogram (ERG) caused by short-term hypertension in human subjects, and their relationship with ocular perfusion pressure (OPP).
Methods: Suction cup technique in 12 normal volunteers with OPs simultaneously recording.
Results: Scotopic and photopic OPs were altered during OPP drop. Scotopic OPs showed more sensitiveness, with higher reduction (from 21% to 47%), when compared to the basal value, than in photopic recordings (from 14% to 34%). In both conditions, the relationship between OPP and OPs presented a steady amplitude before the trough after the +30 step, and rapid recovery after OPP normalisation. ANOVA and correlation analysis confirmed the data.
Conclusion: The ERG OPs seemed to reflect the OPP modification. The features of OPs amplitudes suggest involvement of the retinal autoregulation mechanism and support development for further clinical studies.
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| http://dx.doi.org/10.1016/j.visres.2004.10.027 | DOI Listing |
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