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The Technique of Permanent Pericardial Catheter in Mice.
JACC Basic Transl Sci
October 2024
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Intrapericardial delivery offers a route for heart therapies. Mouse heart size and membrane thickness pose catheterization challenges, hampering pericardium-targeted treatments. The objectives were to develop a mouse surgical technique for pericardial catheter insertion and to assess its suitability for intrapericardial delivery, including use with a myocardial ischemia/reperfusion model.
View Article and Find Full Text PDFA Case Report of Atypical Migratory Shulman Syndrome.
Cureus
September 2024
Department of Pathology, Université Saint-Joseph and Hôtel-Dieu de France University Hospital, Beirut, LBN.
Article Synopsis
- - Eosinophilic fasciitis (EF), also known as Shulman syndrome, is a rare disorder that causes painful swelling and thickening of skin and soft tissues, and can also affect internal organs like the pleura and kidneys.
- - A case report details a 39-year-old patient with unique multifocal skin involvement, discussing symptoms, tissue analysis, possible conditions to consider, treatment options, and the outcomes for the patient.
- - Early diagnosis of EF is essential for effective treatment and improved outcomes, especially when atypical skin lesions are present.
Probable idiopathic hypereosinophilic syndrome: A case report of severe multi-organ eosinophilic involvement in a young male presenting with heart failure.
SAGE Open Med Case Rep
August 2024
Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, Loyola University Health System, Maywood, IL, USA.
Article Synopsis
- Hypereosinophilic syndrome (HES) is marked by high eosinophil levels, possibly affecting multiple organs, especially when severe; diagnosis criteria necessitate a count above 1500 cells/mcL and signs of tissue damage.
- A case study of a 37-year-old firefighter revealed an eosinophil count of 4500 cells/mcL, leading to acute myocarditis and heart failure, despite initial assumptions of pneumonia.
- This situation highlights the need to consider HES in acute heart failure cases in healthy adults, as timely diagnosis and steroid treatment can prevent further complications.
Comprehensive macro and micro views on immune cells in ischemic heart disease.
Cell Prolif
December 2024
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ischemic heart disease (IHD) is a prevalent cardiovascular condition that remains the primary cause of death due to its adverse ventricular remodelling and pathological changes in end-stage heart failure. As a complex pathologic condition, it involves intricate regulatory processes at the cellular and molecular levels. The immune system and cardiovascular system are closely interconnected, with immune cells playing a crucial role in maintaining cardiac health and influencing disease progression.
View Article and Find Full Text PDFAutologous haematopoiesis stem cell transplantation (AHSCT) for treatment-refractory autoimmune diseases in children.
RMD Open
July 2024
Department of Paediatrics and Autoinflammation reference Center Tuebingen (arcT), Universitatsklinikum Tubingen, Tubingen, Baden-Württemberg, Germany
Article Synopsis
- The study aimed to assess the long-term effectiveness and safety of autologous hematopoietic stem cell transplantation (AHSCT) for severe autoimmune diseases in children and adolescents.
- Seven patients with various autoimmune conditions underwent AHSCT, showing a median progression-free survival of 4.2 years and overall survival rate of 100%, with most in clinical remission after a long follow-up.
- Despite some safety concerns, including infections and new autoimmune diseases, the results indicate that AHSCT can be a promising treatment for these challenging cases.
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