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Investigating the plasma electrophoretic protein profile of kids and lambs during the neonatal period: An overview of their immuno-inflammatory status.
Heliyon
November 2024
Department of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, snc, 98168, Messina, Italy.
The study aimed to evaluate how plasma total proteins, their fractions (i.e. albumin, α1-, β-, γ-globulins) and A/G ratio change in lambs and kids over the first month of life.
View Article and Find Full Text PDFAddressing statistical challenges in the analysis of proteomics data with extremely small sample size: a simulation study.
BMC Genomics
November 2024
Institute for Clinical Research and Learning Health Care, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Background: One of the most promising approaches for early and more precise disease prediction and diagnosis is through the inclusion of proteomics data augmented with clinical data. Clinical proteomics data is often characterized by its high dimensionality and extremely limited sample size, posing a significant challenge when employing machine learning techniques for extracting only the most relevant information. Although there is a wide array of statistical techniques and numerous analysis pipelines employed in proteomics data analysis, it is unclear which of these methods produce the most efficient, reproducible, and clinically meaningful results.
View Article and Find Full Text PDFViper Venom Phospholipase A2 Database: The Structural and Functional Anatomy of a Primary Toxin in Envenomation.
Toxins (Basel)
February 2024
Requimte-Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-000 Porto, Portugal.
Article Synopsis
- Viper venom contains phospholipase A2 enzymes (vvPLA2s) and PLA2-like proteins that cause severe muscle and nerve damage during snakebites, which is a major neglected tropical disease.
- A new database has been created featuring the 3D structures of 217 vvPLA2 and PLA2-like proteins, along with data on 79 viper species, to aid scientific research in developing anti-snakebite drugs.
- This study not only examines the structure and toxicity mechanisms of these proteins but also suggests ways to develop effective inhibitors to combat their harmful effects across different viper species.
Innovative System for Delivering Nucleic Acids/Genes Based on Controlled Intracellular Trafficking as Well as Controlled Biodistribution for Nanomedicines.
Biol Pharm Bull
December 2023
Laboratory of Innovative Nanomedicine, Faculty of Pharmaceutical Sciences, Hokkaido University.
This review paper summarizes progress that has been made in the new field of "Controlled Intracellular Trafficking." This involves the development of new systems for delivering plasmid DNA (pDNA), small interfering RNA (siRNA), mRNA, proteins, their escape from endosomes, the mechanism for how they enter the nucleus, how they enter mithochondria and how materials subsequently function within a cell. In addition, strategies for delivering these materials to a selective tissue after intravenous administration was also intensively investigated not only to the liver but also to tumors, lungs, adipose tissue and the spleen.
View Article and Find Full Text PDFMolecular cues for immune cells from small leucine-rich repeat proteoglycans in their extracellular matrix-associated and free forms.
Matrix Biol
November 2023
Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY, United States; Department of Pathology, NYU Grossman School of Medicine, New York, NY, United States. Electronic address:
In this review we highlight emerging immune regulatory functions of lumican, keratocan, fibromodulin, biglycan and decorin, which are members of the small leucine-rich proteoglycans (SLRP) of the extracellular matrix (ECM). These SLRPs have been studied extensively as collagen-fibril regulatory structural components of the skin, cornea, bone and cartilage in homeostasis. However, SLRPs released from a remodeling ECM, or synthesized by activated fibroblasts and immune cells contribute to an ECM-free pool in tissues and circulation, that may have a significant, but poorly understood foot print in inflammation and disease.
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