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Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Fluorescent biosensors offer a powerful tool for tracking and quantifying protein activity in living systems with high temporospatial resolution. However, the expression of genetically encoded fluorescent proteins can interfere with endogenous signaling pathways, potentially leading to developmental and physiological abnormalities. The EKAREV-NLS mouse model, which carries a FRET-based biosensor for monitoring extracellular signal-regulated kinase (ERK) activity, has been widely utilized both in vivo and in vitro across various cell types and organs.
View Article and Find Full Text PDFEpigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA).
Epigenetics
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Perceived discrimination, recognized as a chronic psychosocial stressor, has adverse consequences on health. DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and subsequently affect health outcomes. However, relatively little is known about the effects of perceived discrimination on DNAm.
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The abnormally viscous and thick mucus is a hallmark of cystic fibrosis (CF). How the mutated CF gene causes abnormal mucus remains an unanswered question of paramount interest. Mucus is produced by the hydration of gel-forming mucin macromolecules that are stored in intracellular granules prior to release.
View Article and Find Full Text PDFDifferences and contributors to global cognitive performance in the underrepresented Latinx Parkinson's disease population.
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Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Despite significant progress in understanding the factors influencing cognitive function in Parkinson's disease (PD), there is a notable gap in data representation for the Latinx population. This study aims to evaluate the contributors to and disparities in cognitive performance among Latinx patients with PD. A retrospective analysis was conducted based on cross-sectional data encompassing demographic, environmental, motor, and non-motor disease characteristics from the Latin American Research Consortium on the Genetics of PD (LARGE-PD) and the Parkinson's Progression Markers Initiative (PPMI) cohorts.
View Article and Find Full Text PDFPublic opinion outweighs knowledge: A dual-process framework for understanding acceptance of genetic modification among scientists and laypeople.
Risk Anal
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School of Journalism and Communication, Tsinghua University, Beijing, China.
Communication research on scientific issues has traditionally relied on the deficit model, which posits that increasing scientific knowledge leads to public acceptance. However, this model's effectiveness is questioned due to inconclusive impacts of knowledge on acceptance. To address this, we propose a dual-process framework combining the deficit model (with scientific knowledge as a key predictor) and a normative opinion process model (where perceived majority opinion plays a crucial role) to predict people's risk/benefit perceptions and their support for genetic modification (GM).
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