Sex determination of Drosophila melanogaster and Caeborhabditis elegans has been known in detail. Great progress, is achieved in recent years, is the research of transformer genes, which are those of most important genes in sex determination in both species. In this paper, molecular character, genetic function and the relative genes of transformer genes are particularly described. On the basis,a primary comparison and analysis between the molecular mechanism of sex determination in C.elegans and D. melanogaster are presented.
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