AI Article Synopsis
- A study was conducted to create a rabbit ear model for observing hypertrophic scar formation, using 60 ears from 32 New Zealand white rabbits with full skin defects.
- The healing process was monitored over 12 months after applying silver sulfadiazine cream, with control ears left untreated for comparison.
- Results showed that scar characteristics evolved through overgrowth, maturation, and degeneration, making this model suitable for understanding hypertrophic scars and assessing treatment methods.
Article Abstract
Objective: To establish an animal model of hypertrophic scar on the rabbit ears and to observe the dynamic process of scar formation on the ventral side of the rabbit ears.
Methods: Full skin defect (2 cm x 5 cm in diameter) was created on the ventral side of 60 ears in 32 New Zealand white rabbits. 1% silver sulfadiazine cream was applied to the wounds, and the dressing was changed once a week till wound healing. Four ears without operation were taken as control. Wound healing under natural condition was observed continuously for 12 months after the operation. The scar proliferation on the rabbit ears was observed by light microscope and transmission electron microscope, and the scar index was determined by computer image analyzing system.
Results: The color, thickness and texture of the wounds on the rabbit ears after epithelization underwent a process of scar overgrowth, maturation and degeneration. The change in scar index was in accordance with the wax and wane of scar proliferation.
Conclusion: The hypertrophic scar formed on the ventral side of rabbit ears after natural healing of full thickness skin wounds was similar to that in humans. The results indicated that this animal model was ideal for the study of the developmental mechanism of hypertrophic scars and for the evaluation of the efficacy of the prevention and treatment of hypertrophic scars.
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