The in vitro activity of the histatin derivative P-113, alone or combined with eight antibiotics, was investigated against multidrug-resistant strains isolated from clinical specimens of immunocompromised patients with pneumonia. The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549265 | PMC |
| http://dx.doi.org/10.1128/AAC.49.3.1249-1252.2005 | DOI Listing |
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