Bactericidal activity of human beta-defensin 3 (hBD-3) against Streptococcus mutans and Actinobacillus actinomycetemcomitans was inhibited in a dose-dependent manner by the presence of saliva and/or serum. Increasing the concentration of hBD-3 partially overcame this inhibition. A fast bactericidal effect was observed against both bacterial strains, suggesting a potential therapeutic use for hBD-3 in the local treatment of oral infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549272 | PMC |
| http://dx.doi.org/10.1128/AAC.49.3.1245-1248.2005 | DOI Listing |
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