We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at position 167.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549256 | PMC |
| http://dx.doi.org/10.1128/AAC.49.3.1242-1244.2005 | DOI Listing |
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