AI Article Synopsis
- Dendritic cells form DALIS, which are ubiquitinated protein aggregates that help store antigens and assist in protein degradation during infections.
- Murine macrophages can create similar ubiquitinated protein aggregates, responding to different microbial stimuli in a dose- and time-dependent manner.
- Unlike DALIS, these aggregates do not attract the proteasome, highlighting a functional distinction that emphasizes the importance of DALIS in immune responses.
Article Abstract
In response to a maturation stimulus, dendritic cells undergo the formation of ubiquitinated protein aggregates known as dendritic cell aggresome-like induced structures (DALIS). DALIS are thought to act as Ag storage structures, allowing for the prioritized degradation of proteins during infection. In this study, we demonstrate that murine macrophages can also form ubiquitinated protein aggregates that are indistinguishable from DALIS. These were formed in a dose- and time-dependent manner, and in response to a variety of microbial products. Surprisingly, the proteasome did not accumulate on these ubiquitinated protein structures, further underlining the difference between DALIS and aggresomes. Our studies suggest that DALIS formation is important for the function of Ag-presenting immune cells during infection.
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| http://dx.doi.org/10.4049/jimmunol.174.5.2471 | DOI Listing |
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