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18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Large-Vessel Vasculitis During Active and Inactive Disease Stages Is Associated with the Metabolic Profile, but Not the Macrophage-Related Cytokines: A Proof-of-Concept Study.
Cells
November 2024
Department of Pathophysiology and Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11526 Athens, Greece.
Giant cell arteritis (GCA) is an autoimmune/autoinflammatory disease affecting large vessels in patients over 50 years old. The disease presents as an acute inflammatory response with two phenotypes, cranial GCA and large-vessel vasculitis (LV)-GCA, involving the thoracic aorta and its branches. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) is among the imaging techniques contributing to diagnosing patients with systemic disease.
View Article and Find Full Text PDFCurrent and Emerging Approaches to Imaging Large Vessel Vasculitis.
Circ Cardiovasc Imaging
November 2024
Rheumatology Unit (M.A.M., A.B.A.M., Z.S.W., S.U.), Massachusetts General Hospital and Harvard Medical School, Boston.
Article Synopsis
- Large vessel vasculitides (LVV) are inflammatory disorders that primarily affect large arteries like the aorta, often linked to conditions such as giant cell arteritis and Takayasu arteritis, with age and gender influencing prevalence.
- Giant cell arteritis commonly occurs in individuals over 50, especially women, while Takayasu arteritis typically affects younger women; both require urgent diagnosis to prevent serious complications like blindness or artery damage.
- Noninvasive imaging techniques, such as ultrasound and MRI, have revolutionized the diagnosis and management of LVV, reducing the need for invasive procedures and aiding in monitoring treatment response and disease progression.
18F-FDG-PET/CT Scan for Detection of Large Vessel Involvement in Giant Cell Arteritis: Arteser Spanish Registry.
J Clin Med
October 2024
Rheumatology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL Immunopathology Group, 39008 Santander, Spain.
Imaging studies have transformed the diagnosis of large vessel vasculitis (LVV) involvement in giant cell arteritis (GCA). A positron emission tomography/computed tomography (PET/CT) scan with 18-fluorodeoxyglucose (18F-FDG) has emerged as a valuable tool for assessing LVV. We aimed to determine the utility of an 18F-FDG-PET/CT scan in detecting LVV in GCA in the ARTESER registry.
View Article and Find Full Text PDFSerial assessment of ultrasound sensitivity and scores in patients with giant cell arteritis before and 3 and 10 days after treatment.
Rheumatology (Oxford)
October 2024
Department of Medicine, The Regional Hospital in Horsens, Horsens, Denmark.
Article Synopsis
- The study aimed to assess the effectiveness of vascular ultrasound (US) in detecting giant cell arteritis (GCA) before and after starting glucocorticoid (GC) treatment in patients new to the condition.
- A total of 48 treatment-naïve patients underwent various imaging tests, and US sensitivity showed high initial rates, followed by a decrease in sensitivity at days 3 and 10 after GC treatment, particularly for temporal artery (TA) assessments.
- Findings suggest a rapid reduction in vasculitic signs after 3 days of treatment, emphasizing the need for early US evaluation within this timeframe to ensure accurate GCA diagnosis.
Positron Emission Tomography/Computed Tomography in Polymyalgia Rheumatica: When and for What-A Critical Review.
Diagnostics (Basel)
July 2024
Division of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Polymyalgia rheumatica (PMR) is an inflammatory disease common in people aged 50 years and older. This condition is characterized by the presence of pain and stiffness involving mainly the shoulder and pelvic girdle. Besides the frequent association with giant cell arteritis (GCA), several conditions may mimic PMR or present with PMR features.
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