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Exploring the osteogenic potential of semisynthetic triterpenes from Combretum leprosum: An in vitro and in silico study.
In Vitro Cell Dev Biol Anim
September 2024
Postgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Combretum leprosum Mart. is a plant of the Combretaceae family, widely distributed in the Northeast region of Brazil, popularly used as an anti-inflammatory agent, and rich in triterpenes. This study evaluated in vitro and in silico potential osteogenic of two semisynthetic triterpenes (CL-P2 and CL-P2A) obtained from the pentacyclic triterpene 3β,6β,16β-trihydroxylup-20(29)-ene (CL-1) isolated from C.
View Article and Find Full Text PDF[Influence of chronic immobilization stress on vitamin status in rats fed different diets].
Vopr Pitan
April 2024
Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
The influence of a stress factor, widespread in modern conditions, on the vitamin status has not been studied enough. At the same time, the negative stress impact can be aggravated against the background of unhealthy nutrition, which in turn affects the vitamin status of the organism. In this regard, of the research was to evaluate the effect of chronic restrict stress on the vitamin supply in rats fed a diet with adequate and increased content of fat, sugar and cholesterol.
View Article and Find Full Text PDF[Influence of the rat diet enrichment with oat β-gucans on the assimilation of B group vitamins, mineral elements and lipid metabolism].
Vopr Pitan
April 2024
Siberian State Medical University, Ministry of Health of the Russian Federation, 634050, Tomsk, Russian Federation.
Article Synopsis
- The study aimed to investigate how oat bran rich in β-glucans affects the absorption of vitamins and minerals, particularly in rats with deficiencies in vitamins D, B group, and trace elements like iron, copper, and zinc.
- After a period of 23 days inducing micronutrient deficiencies, rats were given a semi-synthetic diet supplemented with missing micronutrients for 7 days, with some groups also receiving β-glucans.
- Results showed that replenishing vitamins B1, B2, and B6 eliminated deficiencies, while β-glucans enhanced iron absorption, evidenced by increased plasma iron levels and decreased urinary iron excretion.
Deficiency Promotes Hyperlipidemia, Inflammation, and Atherosclerosis in LDL Receptor Knockout Mice.
Arterioscler Thromb Vasc Biol
June 2023
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany (L.A., I.H.-R., M.H., G.L., S.C.S., R.B.).
Background: Genetic variants at the gene locus are strongly associated with plasma lipid traits and the risk of coronary artery disease in humans. Here, we analyzed the consequences of deficiency on lipid metabolism and atherosclerotic lesion formation in atherosclerosis-susceptible mice.
Methods: mice were crossed onto the background to generate double-knockout mice () and fed a semisynthetic, modified AIN76 diet (0.
Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization.
Int J Mol Sci
May 2022
MAX BioPharma Inc., Santa Monica, CA 90404, USA.
Inflammatory responses by the innate and adaptive immune systems protect against infections and are essential to health and survival. Many diseases including atherosclerosis, osteoarthritis, rheumatoid arthritis, psoriasis, and obesity involve persistent chronic inflammation. Currently available anti-inflammatory agents, including non-steroidal anti-inflammatory drugs, steroids, and biologics, are often unsafe for chronic use due to adverse effects.
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