Purpose: To demonstrate a differential response following administration of a free radical scavenger, tempol, in kidneys of hypertensive compared to normotensive rats.
Material And Methods: Data were obtained in spontaneously hypertensive rats (SHR, N = 5). Wistar-Kyoto rats (WKY, N = 6) were used as normotensive controls.
Results: Consistent with prior reports, SHRs show a significant response to tempol (R(2)*decreased from 40.56 +/- 0.66 second(-1) to 28.58 +/- 0.6 second(-1) in medulla, P < 0.05), while WKY rats exhibit a minimal change (R(2)* measuring 22.36 +/- 4.38 second(-1) pre-tempol and 21.57 +/- 4.78 second(-1) post-tempol, in medulla). The post-tempol R(2)* in SHR was found to be comparable to pre-tempol values in WKY rats, suggesting an improved medullary oxygenation in SHRs.
Conclusion: Based on both baseline R(2)* values and the differential effect of the free radical scavenger on renal medullary oxygenation, BOLD MRI can distinguish hypertensive from normal kidney in rats.
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| http://dx.doi.org/10.1002/jmri.20260 | DOI Listing |
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