Purpose: To determine the efficacy of the peroxisome proliferator-activated receptor gamma agonist, pioglitazone, in inhibiting corneal neovascularization.
Methods: Twenty-six adult male Sprague-Dawley rats were randomly divided into three groups. Each group received intrastromal polymer micropellets containing one of the following: Group 1, no active ingredient (n=10); Group 2, vascular endothelial growth factor (VEGF) (n=7); Group 3, VEGF and pioglitazone (n=9). Neovascularization was evaluated 7 days after pellet implantation. After systemic India ink injection, digital photographs of the eyes were taken. The area and density of neovascularization were measured using imaging software.
Results: Mean area of neovascularization was 0.43+/-0.18 mm2 for Group 1, 2.87+/-0.48 mm2 for Group 2 and 2.10+/-0.22 mm2 for Group 3. Statistical analysis showed significant differences between Groups 1 and 2 and Groups 1 and 3. There was no significant difference between Groups 2 and 3. Mean density of neovascularization was 2.16+/-0.66 for Group 1, 27.14+/-2.93 for Group 2 and 12.02+/-2.24 for Group 3. All comparisons between groups were statistically significant (P<0.01).
Conclusions: Pioglitazone is effective in decreasing the density of angiogenesis in a VEGF-induced neovascular rat cornea model. There is possibility of even greater effect with higher doses of the drug. Pioglitazone is a promising drug for the treatment of ocular neovascularization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.exer.2004.10.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of cementation technique and cement type on the amount of excess cement in implant-supported cement-retained crown restorations: An in vitro study.
J Prosthet Dent
December 2024
Professor, Department of Prosthodontics, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Statement Of Problem: Excess cement in implant-supported restorations can lead to peri-implant diseases, and its removal remains a clinical challenge. The optimum method of minimizing excess cement is unclear.
Purpose: The purpose of this in vitro study was to compare 3 cementation techniques and 3 cement types and measure excess cement.
Purpose: This study compares and evaluates the parameters of iridotrabecular contact (ITC) in patients with primary angle closure disease (PACD) with natural lenses and pseudophakia based on anterior segment imaging data from swept-source optical coherence tomography (SS-OCT).
Material And Methods: This retrospective study analyzed data from 92 patients aged 32 to 89 years, and included 56 patients with PACD (43 with natural lenses and 13 with pseudophakia) and 36 in the control group (21 with natural lenses and 15 with pseudophakia). All participants underwent SS-OCT (CASIA2; Tomey Corporation, Japan), which included an assessment of the ITC Index and ITC Area.
Risk prediction criteria for the primary hepatic perivascular epithelioid cell tumour family, including angiomyolipoma: analysis of 132 cases with a literature review.
Histopathology
December 2024
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Aims: The hepatic perivascular epithelioid cell tumour (PEComa), including angiomyolipoma, exhibits diverse morphology and clinical behaviour; however, its prognostic features remain undefined. This study aimed to investigate its histological features and prognostic factors.
Methods And Results: In total, 132 patients were included.
Automated Assessment of Pelvic Longitudinal Rotation Using Computer Vision in Canine Hip Dysplasia Screening.
Vet Sci
December 2024
Department of Veterinary Science, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Canine hip dysplasia (CHD) screening relies on accurate positioning in the ventrodorsal hip extended (VDHE) view, as even mild pelvic rotation can affect CHD scoring and impact breeding decisions. This study aimed to assess the association between pelvic rotation and asymmetry in obturator foramina areas (AOFAs) and to develop a computer vision model for automated AOFA measurement. In the first part, 203 radiographs were analyzed to examine the relationship between pelvic rotation, assessed through asymmetry in iliac wing and obturator foramina widths (AOFWs), and AOFAs.
View Article and Find Full Text PDFBone Regeneration After Sinus Floor Elevation in an Intact Sinus or a Sinus With Prior Large Membrane Perforation: A Preclinical Study Using a Rabbit Sinus Model.
J Clin Periodontol
December 2024
Department of Periodontology, Kyung Hee University College of Dentistry, Periodontal-Implant Clinical Research Institute, Kyung Hee University Medical Center, Seoul, Republic of Korea.
Aim: To determine bone regeneration following sinus floor elevation (SFE) at sites with or without prior sinus membrane perforation.
Materials And Methods: The sinus membranes in the maxillary sinuses of 12 rabbits were intentionally perforated (≥ 5 mm) on one side, followed by application of a collagen matrix. SFE was performed on both sinuses after 8 weeks of healing, presenting two groups: SFE with a previous large sinus membrane perforation (group SFE_Perf), and in an intact sinus (group SFE).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!