Background And Objectives: Very-low-birthweight infants are among the most heavily transfused patients. The objective of this study was to verify if the introduction of a strict guideline would reduce the need for red blood cell transfusions in the first 4 weeks of life in these neonates.
Materials And Methods: This was a multicentre prospective study of two cohorts of very-low-birthweight infants transfused in accordance with the recommendations of a neonatologist (Phase 1) or according to previously published guidelines (Phase 2).
Results: In the first 28 days of life, 102 patients (68.5%) in Phase 1 and 117 (59.7%) in Phase 2 were transfused. The number of transfusions was 1.9 +/- 2.0 in Phase 1 and 1.4 +/- 1.6 in Phase 2 (P = 0.01). After adjusting for gestational age, blood loss and the presence of respiratory distress syndrome, the strict guideline reduced the number of transfusions in 17.6% (IC 95%-30.5% to -2.6%).
Conclusions: The strict guideline was effective in reducing erythrocyte transfusions in very-low-birthweight infants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1423-0410.2005.00607.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The fungal microbiota modulate neonatal oxygen-induced lung injury.
Microbiome
January 2025
Division of Neonatology, Department of Pediatrics, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Background: The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity of prematurity. While the microbiota significantly influences neonatal health, the relationship between the intestinal microbiome, particularly micro-eukaryotic members such as fungi and yeast, and lung injury severity in newborns remains unknown.
Results: Here, we show that the fungal microbiota modulates hyperoxia-induced lung injury severity in very low birth weight premature infants and preclinical pseudohumanized and altered fungal colonization mouse models.
Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China's two-child policy.
BMC Pregnancy Childbirth
January 2025
Department of Health Care, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Background: Since the implementation of China's comprehensive two-child policy, the prevalence of long interpregnancy intervals (IPI) and advanced maternal age has increased. However, previous studies in China have mostly focused on the relationship between short IPIs and adverse perinatal outcomes, while neglecting maternal age as a potential confounder.
Methods: We conducted a retrospective cohort study of 23,899 pregnant women who delivered between January 1, 2017 and December 31, 2019 at Chengdu Women's and Children's Central Hospital and West China Second Hospital of Sichuan University.
Mental Health Outcomes of a National Cohort of Adults Born with Very Low Birthweight.
J Clin Med
December 2024
Canterbury Child Development Research Group, School of Health Sciences, University of Canterbury, Christchurch 8140, New Zealand.
Children born with a very low birthweight (VLBW; <1500 g) and/or very preterm (VPT; <32 weeks) are at increased risk of mental health problems, but adult data are inconsistent. We examined the prevalence of a range of mental health disorders in a national cohort of adults born with a VLBW, as well as associations between gestational age and mental health outcomes. All infants born with a VLBW in New Zealand in 1986 were followed prospectively from birth.
View Article and Find Full Text PDFQuantity of spontaneous touches to body and surface in very preterm and healthy term infants.
Front Psychol
December 2024
Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Background: Spontaneous movements are a crucial part of early motor development. Healthy term infants may produce up to 200 spontaneous touches to their body and surface in 10 minutes with their hands. The existing literature shows differences in early motor development between very preterm (<32 weeks gestation) and healthy term infants.
View Article and Find Full Text PDFExpiration of a state level eviction moratorium in the first or second trimester of pregnancy and perinatal outcomes among Medicaid and uninsured people, 2020-2022.
Health Place
December 2024
Department of Epidemiology, Emory University Rollins School of Public Health, USA.
Goal: Housing insecurity is associated with poor perinatal outcomes. However, we lack information on whether supportive housing policies improve perinatal health. Our goal was to estimate the effect of expiration of a state-level eviction moratoria on adverse maternal and infant outcomes among Medicaid insured individuals residing in states with a state-level moratorium in place at conception in the United States.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!