Gram-positive lactic acid bacteria possess several Multi-Drug Resistance systems (MDRs) that excrete out of the cell a wide variety of mainly cationic lipophilic cytotoxic compounds as well as many clinically relevant antibiotics. These MDRs are either proton/drug antiporters belonging to the major facilitator superfamily of secondary transporters or ATP-dependent primary transporters belonging to the ATP-binding cassette superfamily of transport proteins. Here we summarize the existing data on these MDRs and discuss recent observations that suggest the use of new strategies in the ongoing battle against drug-resistant microbial pathogens.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1389557053402675 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research progress on Sertoli cell secretion during spermatogenesis.
Front Endocrinol (Lausanne)
January 2025
Sichuan Provincial Key Laboratory of Traditional Chinese Medicine Regulation of Metabolic Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Sertoli cells (SCs), as the somatic cells in the testis of male mammals, play a crucial role in the close association with germ cells. The blood-testicular barrier (BTB), established by their tight junctions, provides immune protection to germ cells, leading to their characterization as "sentinel" cells. Moreover, the physiological process of testicular development and spermatogenesis in male animals is intricately tied to the secretory activities of SCs.
View Article and Find Full Text PDFConsensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Reason of "Fast Reconstitution" [Letter].
Clin Cosmet Investig Dermatol
January 2025
Li-An Medical Clinic, Taipei City, 104452, Taiwan.
Reusable Self-Powered Electrochromic Sensor Patch Based on Enzymatic Biofuel Cells for On-Site Visualized Monitoring of Lactic Acid.
Anal Chem
January 2025
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Wearable sensors have broad application potential in motion assessment, health monitoring, and medical diagnosis. However, relying on a specialized instrument for power supply and signal reading makes sensors unsuitable for on-site detection. To solve this problem, a reusable self-powered electrochromic sensor patch based on enzymatic biofuel cells were constructed to realize the on-site visualized monitoring.
View Article and Find Full Text PDFOptimising medium chain carboxylate production in xylan mixed-culture monofermentation.
Bioresour Technol
January 2025
CRETUS, Department of Chemical Engineering, Universidade de Santiago de Compostela 15782 Santiago de Compostela, Spain.
This work investigates the optimization of medium-chain carboxylate (MCC) production through xylan mixed-culture monofermentation. The pH screening in batch assays showed that the hydrolysis stage and selectivity towards MCC precursors were optimised at pH 6. Subsequently, a continuous stirred tank reactor (CSTR) and a Sequential Batch Reactor (SBR) were operated at different Hydraulic Retention Times (HRT), revealing that the SBR at HRT 2 days yielded the highest caproic acid since lactic acid availability and chain elongation process were balanced.
View Article and Find Full Text PDFImprovement of lactic acidosis in pyruvate dehydrogenase complex deficiency using custom-made amino acid-based dialysate for peritoneal dialysis.
Pediatr Nephrol
January 2025
Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong, China.
This case report presents a newborn with pyruvate dehydrogenase complex deficiency who developed significant lactic acidosis and acute kidney injury after birth. Peritoneal dialysis with glucose-based peritoneal dialysis fluid was initially started, but the patient had worsening hyperglycemia and lactic acidosis, likely related to excess glucose reabsorption with shunting to lactate due to the underlying metabolic disorder. As amino acid-based dialysis solution was not available in our formulary, a dialysis fluid was manually created with Vaminolact, which was commonly used in neonatal parenteral nutrition.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!