Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.
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Taste preference and conditioned taste aversion of the metallothionein-1/2 null mice.
Physiol Behav
February 2025
Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan. Electronic address:
To investigate the effects of metallothionein (MT)-1/2 gene knockout on the taste preference and the conditioned taste aversion (CTA), we performed an experiment comparing the behavior of wild type (WT) mice and MT-1/2 null (KO) mice. The taste preference ratio of saccharin solutions (0.1 or 0.
View Article and Find Full Text PDFExposure to potentially harmful excipients in medications among neonates at a state hospital in Malaysia.
Drug Dev Ind Pharm
March 2024
Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Objectives: This study aimed to determine the incidence, types and predictors of Potentially Harmful Excipients (PHE) exposure among hospitalized neonates.
Methods: A prospective observational study was conducted from March to April 2022 in neonatal wards at a state hospital in Malaysia. The PHEs of interest were aspartame, benzalkonium chloride, benzyl alcohol, benzoic acid or benzoates, ethanol, parabens, polysorbate 80, propylene glycol, saccharin sodium, sorbitol and sulfites.
Determination of Optimum Processing Condition of High Protein Laver Chip Using Air-Frying and Reaction Flavor Technologies.
Foods
December 2023
Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon 51140, Republic of Korea.
Article Synopsis
- - This study focused on creating a high-protein, gluten-free laver chip using air-frying and flavor-enhancing technologies through a method called response surface methodology (RSM).
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Lipopolysaccharide (LPS) attenuates the primary conditioning of lithium chloride (LiCl)-induced context aversion but not the secondary conditioning of context aversion or taste avoidance.
Behav Brain Res
February 2024
Graduate Program in Neuroscience, University of Western Ontario, London, Canada; Department of Psychology, University of Western Ontario, London, Canada.
A first-order association can be formed between toxin-induced nausea and a context, as well as nausea and a taste cue. However, comparatively little is understood about second-order associations. The present study examined if the bacterial endotoxin, LPS, could impair the first- and second-order conditioning of context aversion (anticipatory nausea paradigm) and subsequent conditioned taste avoidance (two-bottle task).
View Article and Find Full Text PDFSimultaneous analysis of natural and artificial sweeteners in sugar-free drinks and urine samples by column-switching UHPLC-charged aerosol detection method.
J Chromatogr A
January 2024
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy Yanbian University, Yanji 133002, Jilin Province, China. Electronic address:
Sweeteners are considered an alternative to high-calorie foods or drinks and have been widely used globally. However, the simultaneous separation and detection of high-polarity natural and artificial sweeteners are challenging owing to their broad-spectrum physical and chemical properties. Herein, we developed a column-switching UHPLCCAD method and used it for detecting and quantitating 12 sweeteners, including natural sweeteners (erythritol, mannitol, xylitol, sorbitol and stevioside) and artificial sweeteners (acesulfame potassium, saccharin sodium salt, sodium cyclamate, sucralose, aspartame, alitame and neotame).
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