AI Article Synopsis
- - The case involves an 89-year-old woman with increased plasma cells in her blood, initially suggesting plasma cell leukemia but later identified as a polyclonal increase of immunoglobulins, not a malignant condition.
- - The plasma cells exhibited a distinct set of markers, showing specific antigens like CD19, CD30, CD38, and CD138, while lacking others typically associated with cancerous plasma cells, indicating they were not neoplastic.
- - Additional symptoms such as swollen lymph nodes, enlarged spleen, and elevated soluble interleukin 2 receptor levels suggest the possibility of a broader lymphoproliferative disorder that could be influencing the plasma cell proliferation.
Article Abstract
We describe an 89-year-old woman who presented with prominent plasmacytosis mimicking plasma cell leukemia. The apparent serum M-protein level of > 7 g/dL of gamma mobility was revealed to be a polyclonal increase of immunoglobulins. The plasma cells in the peripheral blood expressed polyclonal surface/cytoplasmic immunoglobulins as well as CD19, CD30, CD38, and CD138 antigens but lacked CD10, CD20, CD25, and CD56. The bone marrow plasma cells showed the CD45+, CD19+, CD56-, MPC-1(-/+), and CD49e- immunophenotype, which was in clear contrast with the immunophenotypes of the neoplastic myeloma cells. Abdominal lymphadenopathy, splenomegaly, and a high level of soluble interleukin 2 receptor may have been reflections of an underlying lymphoproliferative disorder, potentially leading to the polyclonal proliferation of plasma cells.
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| http://dx.doi.org/10.1532/ijh97.04136 | DOI Listing |
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