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Garlic ( L.) Organosulfur Compounds Inhibit Breast Cancer Cell Proliferation by Decreasing Steroid Sulfatase Levels.
Anticancer Res
January 2025
Faculty of Pharmacy, Iryo Sosei University, Fukushima, Japan.
Background/aim: Breast cancer is mostly affected by estrogen, which promotes proliferation, tumorigenesis, and cancer progression. Estrogen sulfotransferase (SULT1E1) catalyzes sulfation to inactivate estrogens, whereas steroid sulfatase (STS) catalyzes estrogen sulfate hydrolysis to activate estrogens in breast cancer cells. Three major organosulfur compounds in garlic (Allium sativum L.
View Article and Find Full Text PDFPhotoresponsive Chemistries for User-Directed Hydrogel Network Modulation to Investigate Cell-Matrix Interactions.
Acc Chem Res
December 2024
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.
ConspectusSynthetic extracellular matrix (ECM) engineering is a highly interdisciplinary field integrating materials and polymer science and engineering, chemistry, cell biology, and medicine to develop innovative strategies to investigate and control cell-matrix interactions. Cellular microenvironments are complex and highly dynamic, changing in response to injury and disease. To capture some of these critical dynamics , biomaterial matrices have been developed with tailorable properties that can be modulated in the presence of cells.
View Article and Find Full Text PDFEffects of free and nanoencapsulated garlic essential oil on growth performance and immune functions in broiler chickens.
Anim Sci J
December 2024
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
The aim of this research was to determine the effect of free and nanoencapsulated garlic essential oil (GEO) on performance, serum biochemistry, and immune functions. Broiler chickens (900 males 1-day-old, Ross 308) were randomly assigned to six treatment diets (0, 75, or 150 mg/kg free GEO and 0 [containing chitosan], 75, or 150 mg/kg nanoencapsulated GEO) in a 2 × 3 factorial arrangement of treatments. The inclusion of nanoencapsulated GEO with a concentration of 75 mg/kg significantly increased the growth performance (p < 0.
View Article and Find Full Text PDFDecoding of the enhancement of saltiness perception by aroma-active compounds during Hunan Larou (smoke-cured bacon) oral processing.
Food Chem
January 2025
China Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China; Key Laboratory of Flavor Science of China General Chamber of Commerce, Beijing Technology and Business University, 100048, China; Food Laboratory of Zhongyuan, Beijing Technology and Business University, 100048, China. Electronic address:
The enhancement of saltiness induced by odrants perceived from the retronasal cavity during Larou oral processing was analyzed. During the oral processing of Xiangtan Larou, the smoky attribute was the dominant when chewing 0-15 times, followed by the savory (15-24 times) and meaty (24-42 times). Partial least squares analysis predicted 33 aroma compounds from the retronasal cavity significantly (p < 0.
View Article and Find Full Text PDFAssessment of the antileishmanial activity of diallyl sulfide combined with meglumine antimoniate on Leishmania major: Molecular docking, in vitro, and animal model.
PLoS One
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Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Currently, no safe vaccine against leishmaniasis is available. So far, different control strategies against numerous reservoir hosts and biological vectors have not been environment-friendly and feasible. Hence, employing medicinal components and conventional drugs could be a promising approach to developing novel therapeutic alternatives.
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