AI Article Synopsis
- The study examined how cool temperatures affect the contraction of smooth muscle in guinea pig taenia caeci when exposed to neurotransmitters like acetylcholine (ACh) and 5-hydroxytryptamine (5-HT).
- Lower temperatures (30°C) were found to significantly increase the contraction response to both ACh and 5-HT compared to body temperature (37°C).
- The results suggest that the enhanced contractile response at lower temperatures might involve increased intracellular calcium levels, as indicated by stronger contractions when calcium and caffeine were introduced at cooler temperatures.
Article Abstract
Isometric contraction of isolated guinea-pig taenia caeci was induced with acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) at 37 and 30 degrees C to investigate the effect of hypothermia on the response of smooth muscle to neurotransmitters. Lowering the temperature increased the amplitude of contraction in response to 10(-6) M ACh. Contraction in response to 10(-6) M 5-HT was also greater at 30 degrees C. 5-HT-contraction was not inhibited by atropine, but was inhibited by ketanserin. Calcium-contraction was also induced in an isosmotic high potassium solution. The amplitude of the contraction elicited by 5 x 10(-3) M Ca was significantly greater at 30 degrees C, and was inhibited by verapamil. The amplitude of the contractile response to 5 x 10(-3) M caffeine was also greater at 30 degrees C than at 37 degrees C. The finding that both calcium- and caffeine-contraction were enhanced at low temperature raises the possibility that intracellular calcium participate in cold-induced enhancement of contraction.
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