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Exploring the Structure and Nucleic Acid Interactions of the Leishmania sp. Telomerase Reverse Transcriptase N-Terminal Region.
Arch Biochem Biophys
January 2025
Department of Chemical and Biological Sciences, Biosciences Institute, São Paulo State University (UNESP) - Botucatu-SP, Brazil. Electronic address:
Leishmaniasis is a neglected tropical disease caused by protozoans of the Leishmania genus, against which no effective treatment or control is available. Like other eukaryotes, parasite telomeres are maintained by telomerase, a ribonucleoprotein complex vital for genome stability. Its protein component, TERT (telomerase reverse transcriptase), presents four structural and functional domains, with the TEN (Telomerase N-terminal) and TRBD (Telomerase RNA-binding) located at its N-terminal.
View Article and Find Full Text PDFValidation of an improved reference freeze-dried direct agglutination test for detecting leishmaniasis in the canine reservoir.
Access Microbiol
January 2025
Department of Medical Laboratory Science, Faculty of Medical and Health Sciences, Liwa College, Abu Dhabi, UAE.
Proper identification and management of post-kala-azar dermal leishmaniasis (PKDL) and canine leishmaniasis (CanL) cases are among the prerequisites to the effective control of visceral leishmaniasis worldwide. Unlike PKDL, CanL still awaits effective improvement because of its cryptic nature, absence of parasites in lesions or lymph nodes and not complete sensitivity of some diagnostic tools in use. Because of the need for certain skills and equipment, both the liquid direct agglutination test and freeze-dried direct agglutination test (FD-DAT) versions are, in comparison with the indirect immunofluorescence antibody test (IFAT) or enzyme-linked immunosorbent assay (ELISA), practical and feasible diagnostic alternatives.
View Article and Find Full Text PDFPharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages.
PLoS Negl Trop Dis
January 2025
Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Macrophages represent a fundamental component of the innate immune system that play a critical role in detecting and responding to pathogens as well as danger signals. Leishmania spp. infections lead to a notable alteration in macrophage metabolism, whereby infected cells display heightened energy metabolism that is linked to the integrity of host mitochondria.
View Article and Find Full Text PDFRapid isothermal molecular tests to discriminate between Leishmania braziliensis and Leishmania infantum infections in dogs.
Parasit Vectors
January 2025
Aggeu Magalhães Institute, Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil.
Background: We standardized two recombinase polymerase amplification (RPA) assays coupled with lateral flow (LF) strips for the detection of Leishmania braziliensis and Leishmania infantum kinetoplast DNA (kDNA).
Methods: The RPA-LF assays were tested at different temperatures and reaction times, using DNA from cultured L. braziliensis and L.
Enhanced Detection of Leishmania Parasites in Microscopic Images Using Machine Learning Models.
Sensors (Basel)
December 2024
Facultad de Ingeniería, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Cutaneous leishmaniasis is a parasitic disease that poses significant diagnostic challenges due to the variability of results and reliance on operator expertise. This study addresses the development of a system based on machine learning algorithms to detect spp. parasite in direct smear microscopy images, contributing to the diagnosis of cutaneous leishmaniasis.
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