AI Article Synopsis
- A case of metachronous transitional cell carcinoma (TCC) of the prostatic urethra was reported in a 56-year-old male patient with a history of nephroureterectomy for urothelial neoplasia.
- Cystourethroscopy revealed suspicious lesions leading to a diagnosis of high-grade superficial TCC, followed by BCG instillation and reevaluation procedures.
- Despite treatment, the cancer progressed to infiltrating TCC with lymph node involvement, and chemotherapy proved ineffective, highlighting the aggressive nature and poor prognosis of such cases.
Article Abstract
Objectives: We report one case of Metacronous transitional cell carcinoma (TCC) of the prostatic urethra in a patient with history of left nephroureterectomy 22 years before for urothelial neoplasia of the upper urinary tract.
Methods: We describe the case of a 56-year-old male patient who presents with oligosymptomatic hematuria for several months. Cystourethroscopy showed irregular hyperemic lesions in the prostatic urethra, cold biopsy of which showed urothelial atypia. Pathology report of fragments of a posterior transurethral resection (TUR) was compatible with high-grade superficial transitional cell neoplasia. Instillation of Bacillus Calmette-Guerin (BCG) was indicated. Reevaluation TUR was performed.
Results: Pathologic report of new samples showed TCC infiltrating the prostatic stroma. The extension study showed ilioobturator adenopathies. Chemotherapy did not achieve significant results. Radical surgery was rejected.
Conclusions: We emphasize the notable metachronous character of the transitional cell carcinoma of the prostatic urethra with respect to the upper urinary tract TCC. We also point out the metastasic capacity of these neoplasias, as well as the bad prognosis of those cases in which chemotherapy is not effective.
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