Objective: To study, the high polar media-water extraction process of Herba epimedii with the microwave technology.

Method: The single parameters of extraction process was investigated with dry extract yield and extraction efficiency of icariin as content index.

Result: Through studying the single parameter, the optimal conditions are as follows: 70% ethanol as wetting solvent, volume of solvent to weight of material equal to 6:1 in wetting, 30 min wetting time, 2.5 min microwave irradiation time, volume of solvent to weight of material equal to 50:1 in extraction process, 10 min microwave-assisted extraction time.

Conclusion: Compared with conventional methods, microwave-assisted extraction (MAE) after Microwave Pretreament (MP) of raw material was higher extraction efficiency and time-saving.

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