The study describes new pathologic entities, the splenohepatic steal-syndrome and the gastroduodenal steal-syndrome, which could be demonstrated by angiography in 17 patients before and after liver transplantation. After the first observation of a splenohepatic steal-syndrome in a patient with unexplained elevation of hepatic enzymes after liver transplantation, a prospective angiographic study was performed, including all liver transplant recipients and patients after liver transplantation with unexplained impaired liver function tests. 9 splenohepatic steal-syndromes could be demonstrated before and 7 after hepatic transplantation, one gastroduodenal steal was seen after liver transplantation. The different therapeutic modalities are discussed.
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JAMA Surg
January 2025
Comprehensive Transplant Center, Division of Transplant Surgery, Department of Surgery, Northwestern University, Feinberg School of Medicine, Northwestern Medicine, Chicago, Illinois.
JAMA Surg
January 2025
Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix.
Importance: Normothermic machine perfusion (NMP) has been shown to reduce peritransplant complications. Despite increasing NMP use in liver transplant (LT), there is a scarcity of real-world clinical experience data.
Objective: To compare LT outcomes between donation after brain death (DBD) and donation after circulatory death (DCD) allografts preserved with NMP or static cold storage (SCS).
Ann Surg Oncol
January 2025
Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Digestives et Hépatiques, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.
Hepatol Commun
February 2025
Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Background: Cell therapy demonstrates promising potential as a substitute therapeutic approach for liver cirrhosis. We have developed a strategy to effectively expand murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs) in vitro. The primary objective of the present study was to apply HepLPCs to the treatment of liver cirrhosis and to elucidate the underlying mechanisms responsible for their therapeutic efficacy.
View Article and Find Full Text PDFSurg Infect (Larchmt)
January 2025
Ministry of Education, Key Laboratory of Surgical Critical Care and Life Support (Xi'an Jiaotong University), Xi'an, People's Republic of China.
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