Myocardial hypoxia is accompanied by increased epicardial potassium activity. In this experimental study in rabbits (n = 13), with ion-selective probes, we correlated our findings with an exact evaluation of myocardial oxygen tension, hemodynamic data and arterial and venous blood gas analysis. The epicardial potassium activity had good correlation with these parameters (pm = -0.95, pco = -0.93 and pa = -0.72, pv = -0.96, respectively). Therefore, the clinical use of these electrodes can be recommended for continuous monitoring in intensive care units.
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http://dx.doi.org/10.1088/0967-3334/25/6/n02 | DOI Listing |
Talanta
November 2024
Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, 980-8579, Japan; Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai, Miyagi, 980-0845, Japan. Electronic address:
The monitoring of ion homeostasis in vivo is of paramount importance due to its critical functions in biological systems. However, current leading technologies for creating ion-selective electrodes often fall short of the requirements for in vivo applications in terms of multiplexity, miniaturization, and flexibility. To address this gap, we introduce an integrated multiplexed ion monitoring probe created from thermally drawn multi-electrode polymer fiber, aimed at enhancing in vivo ion homeostasis studies.
View Article and Find Full Text PDFHeliyon
November 2024
Department for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 172, 210009 Nanjing, PR China.
Introduction: With advancements in detection equipment and an increase in the frequency of examinations, thyroid nodules and goiter in children have garnered attention.
Objective: This study aims to determine the effects of high iodine and fluoride exposure on thyroid nodules and goiter in school-aged children.
Methods: We recruited children aged 8 to 12 from rural Jiangsu, China, based on the concentrations of iodine and fluoride in local drinking water and urine.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Department of Chemistry, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China; National Experimental Teaching Demonstration Center for Food Science and Engineering (Shanghai Ocean University), Shanghai 201306, China; Marine Biomedical Science and Technology Innovation Platform of Lingang Special Area, Shanghai 201306, China. Electronic address:
Selective response is the key index to evaluate the performance of polymeric carbon nitride (PCN)-based heavy metal ion fluorescence sensors. Herein, to explore the role of cyano groups on selectivity, four kinds of PCN, including PCN-Cl, PCN-Ac, PCN-B and PCN-K were prepared by the molten salt method of sodium chloride and sodium acetate, the reduction method of sodium borohydride and the etching method of potassium hydroxide, respectively. These PCNs exhibited different surface cyano characteristics, but all of them had significant blue emission under ultraviolet excitation.
View Article and Find Full Text PDFACS Sens
August 2024
Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.
Owing to the biological significance of Cl in cells, several chemical fluorescent probes and biosensors have been constructed to monitor this anion in the cytosol and subcellular organelles. However, a fluorescent probe for the selective detection of nuclear Cl has not been described thus far. In the current study, we developed the first nuclear Cl-selective biosensor, Cl-YFP-NLS, whose fluorescence was effectively quenched by this anion, and demonstrated that it is an efficient and powerful tool for determining the levels of nuclear Cl.
View Article and Find Full Text PDFAnal Chem
July 2024
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
The nuclear pore complex (NPC) is a proteinaceous nanopore that solely and selectively regulates the molecular transport between the cytoplasm and nucleus of a eukaryotic cell. The ∼50 nm-diameter pore of the NPC perforates the double-membrane nuclear envelope to mediate both passive and facilitated molecular transport, thereby playing paramount biological and biomedical roles. Herein, we visualize single NPCs by scanning electrochemical microscopy (SECM).
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