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B12-retro-riboswitches: guanosyl-induced constitutional switching of B12 coenzymes.
Chemistry
July 2008
Institute of Organic Chemistry and Centre of Molecular Biosciences, Leopold-Franzens Universität Innsbruck, 6020 Innsbruck, Austria.
Complete B12 derivatives are natural "molecular switches" as a result of the coordinative switch ("base on" or "base off") of the natural nucleotide base. Certain predesigned B12-nucleotide conjugates were shown recently to behave as "retro riboswitches", in which the nucleotide environment modified the equilibrium between these two isomeric B12 structures. In contrast, the "reverse" situation has been discovered in natural B12 riboswitches, in which the binding of coenzyme B12 induces a conformational switch in the RNA species.
View Article and Find Full Text PDFB12-retro-riboswitches: constitutional switching of B12 coenzymes induced by nucleotides.
Angew Chem Int Ed Engl
April 2005
Institut für Organische Chemie, Innrain 52a.
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