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Antifouling Immunomodulatory Copolymer Architectures That Inhibit the Fibrosis of Implants.
Adv Mater
December 2024
David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Immune reactions to medical implants often lead to encapsulation by fibrotic tissue and impaired device function. This process is thought to initiate by protein adsorption, which enables immune cells to attach and mount an inflammatory response. Previously, several antifibrotic materials have been either designed to reduce protein adsorption or discovered via high-throughput screens (HTS) to favorably regulate inflammation.
View Article and Find Full Text PDFEstablishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats.
Geroscience
December 2024
Department of Aging and Longevity Research, Kumamoto University, 2-2-1 Honjo, Chuo-Ku, Kumamoto, 860-0811, Japan.
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diverged 26 million years ago from its close relative, the naked mole-rat (NMR). While the properties of NMR cultured fibroblasts have been extensively studied and have revealed several unusual features of this cancer-resistant, long-lived species, comparative DMR studies are extremely limited. We optimized conditions for successfully culturing primary DMR skin fibroblasts and also established immortalized DMR cells using simian virus 40 early region expression.
View Article and Find Full Text PDFCharacterization of the enzyme for 5-hydroxymethyluridine production and its role in silencing transposable elements in dinoflagellates.
Proc Natl Acad Sci U S A
November 2024
Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong & Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Shenzhen 518055, China.
Dinoflagellate chromosomes are extraordinary, as their organization is independent of architectural nucleosomes unlike typical eukaryotes and shows a cholesteric liquid crystal state. 5-hydroxymethyluridine (5hmU) is present at unusually high levels and its function remains an enigma in dinoflagellates chromosomal DNA for several decades. Here, we demonstrate that 5hmU contents vary among different dinoflagellates and are generated through thymidine hydroxylation.
View Article and Find Full Text PDFHunger, Satiety, and Their Vulnerabilities.
Nutrients
September 2024
Department of Pediatrics, Herbert Wertheim School of Public Health and Human Longevity Science and Psychiatry, University of California San Diego, San Diego, CA 92161, USA.
Article Synopsis
- - The psychological states of hunger and satiety involve learning and memory processes tied to the medial temporal lobes (MTL), especially the hippocampus, which can be damaged by various conditions.
- - The document explores how MTL pathology influences ingestive behaviors in various contexts, including obesity, anorexia nervosa, temporal lobe epilepsy, and post-traumatic stress disorder.
- - The findings suggest that impairments in the MTL are connected to problems with hunger and satiety, highlighting the need for new treatment approaches aimed at regulating appetite based on these insights.
Recent advances in functional nucleic acid decorated nanomaterials for cancer imaging and therapy.
Biomed Pharmacother
May 2024
Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China. Electronic address:
Nanomaterials possess unusual physicochemical properties including unique optical, magnetic, electronic properties, and large surface-to-volume ratio. However, nanomaterials face some challenges when they were applied in the field of biomedicine. For example, some nanomaterials suffer from the limitations such as poor selectivity and biocompatibility, low stability, and solubility.
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