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Indocyanine green faecal excretion holds potential for diagnosis of neonatal biliary atresia.
Clin Exp Hepatol
March 2024
Pediatric Surgery, Nagoya City University Midori Municipal Hospital, Japan.
Aim Of The Study: This study aimed to establish an objective, simple, and minimally invasive screening method to detect patients with biliary atresia during neonatal checkups by using indocyanine green (ICG) fluorescence in the stool.
Material And Methods: We produced a rat model of extrahepatic biliary obstruction (group O, = 9) and compared the stools from these rats with those of control group rats (group C, = 6) by a fluorescence technique. ICG was administered (0.
Clonorchis sinensis Promotes Intrahepatic Cholangiocarcinoma Progression by Activating FASN-Mediated Fatty Acid Metabolism.
J Gastroenterol Hepatol
January 2025
Department of Oncology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Article Synopsis
- Clonorchis sinensis infection significantly worsens overall survival rates in patients with intrahepatic cholangiocarcinoma (ICC) compared to those without the infection.
- Researchers used RNA sequencing and animal models to investigate how C. sinensis infection facilitates the progression of ICC.
- The study found that C. sinensis infection leads to increased expression of fatty acid synthase (FASN), which promotes fatty acid synthesis and tumor growth, suggesting a potential new target for treatment in ICC patients infected with C. sinensis.
TCR Repertoire Analysis During Therapeutic Interventions in Liver Diseases Using Next-Generation Sequencing.
J Gastroenterol Hepatol
December 2024
Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Background And Aim: The T cell receptor (TCR) can recognize a vast number of antigens and is closely associated with the pathogenesis of various diseases including autoimmune diseases and malignancies. However, the clinical significance of the TCR repertoire and its post-treatment changes remain unclear in liver diseases.
Methods: We performed next-generation sequencing (NGS)-based TCR analysis using DNA obtained from peripheral blood mononuclear cells (PBMCs) of healthy donors (HD, n = 5), primary biliary cholangitis (PBC, n = 5), autoimmune hepatitis (AIH, n = 5), and hepatocellular carcinoma (HCC, n = 5) and evaluated the changes after treatment.
Indocyanine green clearance's association with liver function in paediatric liver disease.
Acta Paediatr
November 2024
Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Aim: Indocyanine green (ICG) clearance, a sensitive biomarker for liver function, has not been validated in children. We assessed the association between ICG clearance and liver function in children with liver disease.
Methods: ICG plasma disappearance rate (ICG-PDR, %/min) was measured in children with liver disease.
Gallbladder sludge and microlithiasis disappearance in a cystic fibrosis patient 1 year after triple combination therapy initiation.
Clin Case Rep
October 2024
Dipartimento Materno Infantile UOSD CRR Fibrosi Cistica Ospedale "San Liberatore" Teramo Italy.
Gallstones, microlithiasis, gallbladder sludge, and micro-gallbladder are frequently reported in cystic fibrosis patients, and modulators could modify gallbladder disease, probably reducing biliary secretions viscosity.
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