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Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19.
Mol Biol Rep
January 2025
Department of Molecular Biology and Genetics, Faculty of Art and Science, Tokat Gaziosmanpasa University, Tokat, 60200, Türkiye.
Background: SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junction, cell proliferation, differentiation and apoptosis.
View Article and Find Full Text PDFQuestion and answers on long-acting therapy with cabotegravir and rilpivirine in people with HIV.
J Antimicrob Chemother
January 2025
Infectious Diseases' Specialist Freelance, Fabro, Italy.
Modern ART is evolving, allowing the use of new drug formulations and alternative routes of administration to oral therapy. Long-acting (LA) cabotegravir and rilpivirine, the first fully injectable antiretroviral regimen approved for clinical use, is a test case for this new route of administration, and an innovation with implications for the quality of life of people with HIV (PWH). However, its use requires a reorganization of outpatient clinics and outpatient services, and a number of issues remain to be defined regarding the management of PWH on LA drugs, including the correct selection of people who can be treated with LA cabotegravir and rilpivirine.
View Article and Find Full Text PDFMother-child dyads living with HIV in the Western Cape, South Africa: Undetectable = Undetectable?
J Int AIDS Soc
February 2025
Centre for Integrated Data and Epidemiological Research, School of Public Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Introduction: Globally, children living with HIV continue to lag behind UNAIDS targets for viral suppression (VS). Because studies with linked mother-child data are limited, we describe VS and associated factors among young children in a setting with early infant HIV testing (at birth, age 10 weeks and 6 months) and early protease inhibitor-based first-line antiretroviral therapy (ART).
Methods: We analysed routinely collected mother-child data for children living with HIV born 2018-2022 in Western Cape province, South Africa (followed through mid-2023).
Designing Supported Nanoparticles via Synergistic Ex-Solution and Phosphorization for Tailored Active Site Generation.
Adv Mater
January 2025
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Supported nanoparticles incorporating catalytically attractive nonmetal elements have gained significant attention as a promising strategy for enhancing catalytic activity in various industrial applications. This study presents an innovative one-pot synthesis method for fabricating hybrid catalysts, which simultaneously modifies surface properties through the precipitation of nanoparticles with the concurrent incorporation of nonmetal elements. The underlying concept is to synchronize the temperature required for particle formation with that of nonmetal incorporation by adjusting the oxygen chemical potential of the host oxide.
View Article and Find Full Text PDFSBERO: Skill Al-Biruni Earth Radius Optimization for Alzheimer's Disease Classification Using Magnetic Resonance Image.
NMR Biomed
March 2025
Department of AIML, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by progressive memory loss and cognitive decline, often affecting behavior and speech. Early detection of AD remains a challenge due to its symptomatic overlap with normal aging and other cognitive disorders, necessitating precise classification methods. This paper proposes a novel Skill Al-Biruni Earth Radius Optimization-enabled Deep Spiking Neural Network (SBERO_Deep SNN) for AD classification using magnetic resonance imaging (MRI).
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