Variants of a lightness effect described by [Todorovic's, D. (1997). Lightness and junctions. Perception, 26, 379] were studied to quantify the failure of lightness constancy as a function of target luminance and target size. Todorovic's effect is similar to White's effect. Simultaneous lightness contrast appears to operate selectively between stimuli belonging to the same perceptual group, and not between stimuli of equal proximity belonging to different perceptual groups. We found that mid-gray targets grouped with a white contextual stimulus were matched on average to a darker-than-veridical gray. Those grouped with a black contextual stimulus were matched on average veridically. This is consistent with 'anchoring' effects observed in simple two-stimulus displays. However, target luminance had an effect that was not captured by mid-level target luminance data or data averaged across target luminances. For both white and black contextual stimuli, light-gray targets were matched to a darker-than-veridical gray and the direction of this error shifted toward the lighter-than-veridical direction as the luminance of the target was lowered. The result was a constant difference between the perceived lightnesses of targets presented with white and black contextual stimuli. Target size had no effect on perceived lightness. These data imply that the Todorovic-White effect can be characterized as lightness assimilation rather than as lightness contrast. By accounting for compression as well as the Todorovic-White effect, assimilation is the more general explanation.
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http://dx.doi.org/10.1016/j.visres.2004.10.025 | DOI Listing |
Epilepsia
January 2025
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Objective: Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most important causes of morbidity in adult people with TSC (pwTSC). mTOR is a key player in inflammation, which in turn could influence TSC-related clinical manifestations.
View Article and Find Full Text PDFJ Dtsch Dermatol Ges
January 2025
Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Background And Objectives: Patients with cutaneous lymphomas (CL) are at an increased risk of developing secondary malignancies. This study aimed to assess the frequency of association between CL and Kaposi sarcoma (KS) and to identify factors that may promote the co-occurrence of these two diseases.
Patients And Methods: On January 25, 2024, we conducted a systematic search of four electronic medical databases to identify all published cases of KS associated with CL.
J Med Chem
January 2025
Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
The main protease M is a clinically validated target to treat infections by the coronavirus SARS-CoV-2. Among the first reported M inhibitors was the peptidomimetic α-ketoamide , whose cocrystal structure with M paved the way for multiple lead-finding studies. We established structure-activity relationships for the series by modifying residues at the P1', P3, and P4 sites.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Department of Biochemistry, University of Zurich, Winterthurerstrass 190, 8057 Zurich, Switzerland.
Type III clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) systems (type III CRISPR-Cas systems) use guide RNAs to recognize RNA transcripts of foreign genetic elements, which triggers the generation of cyclic oligoadenylate (cOA) second messengers by the Cas10 subunit of the type III effector complex. In turn, cOAs bind and activate ancillary effector proteins to reinforce the host immune response. Type III systems utilize distinct cOAs, including cyclic tri- (cA3), tetra- (cA4) and hexa-adenylates (cA6).
View Article and Find Full Text PDFCurr Med Imaging
January 2025
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong An Road, Xicheng District, Beijing 100050, China.
Background: The neuroanatomical basis of white matter fiber tracts in gait impairments in individuals suffering from Parkinson's Disease (PD) is unclear.
Methods: Twenty-four individuals living with PD and 29 Healthy Controls (HCs) were included. For each participant, two-shell High Angular Resolution Diffusion Imaging (HARDI) and high-resolution 3D structural images were acquired using the 3T MRI.
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