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Influence of the ERK/CHGB pathway in breast cancer progression under chronic stress.
Int J Biochem Cell Biol
January 2025
Oncology Department, Yan 'an Hospital of Kunming Medical University, Kunming, Yunnan, China.
Background: Breast cancer is one of the most common malignancies among women, and its development involves a variety of complex molecular mechanisms. Extracellular signal-regulated kinase (ERK) and Chromogranin B (CHGB) are known to play key roles in various cancers. This study aims to explore the impact of the ERK/CHGB pathway in a chronic stress environment simulated by salbutamol on the development of breast cancer.
View Article and Find Full Text PDFG-Protein-Coupled Receptor Surface Creates a Favorable Pathway for Membrane Permeation of Drug Molecules.
J Phys Chem Lett
December 2024
Frankfurt Institute for Advanced Studies, Ruth-Moufang-Straße 1, 60438 Frankfurt am Main, Germany.
Article Synopsis
- G-protein-coupled receptors (GPCRs), especially the β2-adrenergic receptor (β2AR), are vital for drug targeting in treating pulmonary diseases.
- Our study used coarse-grained molecular dynamics simulations to analyze how salmeterol and salbutamol interact with membranes and the β2AR, revealing that drug molecules often use the receptor surface for better membrane permeability.
- Findings indicate that enhancing drug interactions with GPCR surfaces could improve therapeutic effectiveness, presenting new avenues for drug development.
Correlation Between Vitamin E Levels and Cholesterol, Vitamin D, and Frequency of Pulmonary Exacerbations in Children With Cystic Fibrosis.
Cureus
November 2024
Department of Public Health, The Ministry of Health, Manama, BHR.
Introduction Children with cystic fibrosis (CF) have lipid maldigestion due to pancreatic insufficiency, which causes malabsorption of fat-soluble vitamins. The primary objective of this study was to assess the prevalence of vitamin E deficiency among children with CF. The secondary objective was to examine the correlation between vitamin E levels with demographic data, laboratory findings, and the number of pulmonary exacerbations.
View Article and Find Full Text PDFNon-dispensed prescriptions - A nationwide descriptive study.
Explor Res Clin Soc Pharm
December 2024
Research Unit, The Social Insurance Institution of Finland (Kela), Helsinki, Finland.
Background: Medication non-adherence is associated with suboptimal health outcomes, higher mortality, and increased healthcare costs.
Objective: The aim of this study was to estimate the number and share of non-dispensed prescriptions at a national level and in specific patient and medicine subgroups.
Methods: The study was a nationwide retrospective register-based study.
Incorporating Aeroallergen Exposure Metrics into Clinical Asthma Care: A Pilot Study Using A Mixed-Methods Survey to Assess Aeroallergen Knowledge, Perceived Asthma Control, and Mitigation Strategies in Households of Children with Asthma.
Pediatr Allergy Immunol Pulmonol
December 2024
Department of Civil, Environmental, and Geodetic Engineering, The Ohio State University, Columbus, Ohio, USA.
Mitigation of household allergens is associated with the reduction of asthma exacerbations in those with allergic asthma and is recommended in recent asthma guidelines. However, we need to better understand patient knowledge of aeroallergens in their homes prior to integrating direct allergen measurement methods into standard asthma care. We conducted a mixed-methods sequential pilot study consisting of a survey and virtual interview with caregivers of children aged 3 to 15 with asthma diagnosis (any severity) about asthma control, household environment, mitigation knowledge and strategies, and knowledge of allergens and asthma.
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