AI Article Synopsis
- Neurons in the hypothalamus detect changes in glucose levels, which is crucial for regulating energy and metabolism.
- The enzyme glucokinase (GK), essential for glucose sensing in pancreatic beta cells, is present in both embryonic and adult hypothalamus, contributing to about 20% of total hexokinase activity.
- This suggests that glucose sensing in the hypothalamus starts early in development, before glucose signaling mechanisms mature in the liver.
Article Abstract
Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (beta)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.
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| http://dx.doi.org/10.1016/j.devbrainres.2004.11.001 | DOI Listing |
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