AI Article Synopsis
- The study explores the current trends in understanding how the endothelium contributes to the antithrombotic function within vascular tissue engineering.
- Various factors influencing this function were analyzed, including the source of endothelial cells, matrix material properties, cell culture techniques, and gene modifications.
- The findings emphasize that optimizing antithrombotic capabilities in engineered tissues necessitates more research on cell sources, materials, culture methods, and particularly gene modification strategies.
Article Abstract
Objective: To investigate the current situation and developing trend of antithrombotic function study of endothelium in vascular tissue engineering.
Methods: The effect of several elements on the antithrombotic ability of endothelium, including the source of endothelium, the characteristic of the matrix materials, the cell culture methods, and the endothelium's gene modification were analyzed.
Results: The normal antithrombotic function of tissue engineered vascular relied on the source of endothelium, gene modification of seeding cells, the cell culture methods in vitro, and the characteristic of the scaffolds.
Conclusion: The establishment of an ideal antithrombotic functional tissue engineering vascular still requires further studies in various aspects including seeding cells, matrix materials, and cell culture methods. Gene modification of vascular endothelium, which improves the antithrombotic ability, deserves more attention.
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