AI Article Synopsis
- The incidence of celiac disease, including silent forms, is increasing globally, prompting a review of recent research in the field.
- New proteomic techniques and an advanced animal model are helping to identify key gliadin epitopes responsible for celiac disease development.
- Despite progress, many gliadin components are still linked to the disease, and small bowel biopsies continue to be the primary method for diagnosis and treatment monitoring.
Article Abstract
Purpose Of Review: The number of diagnoses of celiac disease, especially "silent" forms continues to rise world-wide. This review aims to summarize critically recent research in celiac disease.
Recent Findings: New proteomic approaches with the development of a possible powerful animal model have potentially furthered the isolation of the epitopes within gliadin, and other related proteins, that are critical for the development of celiac disease.
Summary: The number of potential disease-triggering gliadin components remains large. Small bowel biopsies remain the gold-standard for both diagnosis and monitoring of treatment.
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| http://dx.doi.org/10.1097/00001574-200403000-00008 | DOI Listing |
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