Two new triterpenes from the seeds of Trichosanthes cucumeroides.

Nat Prod Res

Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, 16 Dongzhimennei Nanxiaojie, Dongcheng, Beijing 100700, China.

Published: April 2005

Two new triterpenes named 7-oxodihydrokarounitriol (1) and 7,11-dioxodihydrokarounidiol (2), and one known triterpene, 7-oxodihydrokarounidiol (3), were isolated from the unsaponifiable matter of the seeds of Trichosanthes cucumeroides. The structures of 1 and 2 were elucidated as (3alpha, 11beta, 13alpha, 14beta, 20alpha)-3,11,29-trihydroxy-13-methyl-26-norolean-8-ene-7-one, and (3alpha,13alpha,14beta,20alpha)-3,29-dihydroxy-13-methyl-26-norolean-8-ene-7,11-dione on the basis of extensive NMR (1H, 13C, 1H-1H COSY, DEPT, HMQC, HMBC and NOESY) and MS studies.

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http://dx.doi.org/10.1080/1478641042000223790DOI Listing

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