AI Article Synopsis
- * In an experiment with rats, different resuscitation fluids like normal saline, bicarbonate Ringer's, and ketone Ringer's were tested, while some rats did not receive resuscitation.
- * The findings showed that resuscitated rats had lower cell death (apoptosis) in their lungs and livers compared to those that weren't resuscitated, suggesting that the right fluids can help protect cells during shock.
Article Abstract
Background: Recent data suggest that the type of resuscitation fluid used to treat hemorrhagic shock contributes to cellular dysfunction
Methods: Rats were hemorrhaged, exposed to a hypovolemic shock period for 75 minutes, and then resuscitated for 1 hour. Treatment animals were assigned randomly to lactate Ringer's solution, normal saline solution, bicarbonate Ringer's solution, hypertonic saline solution, rat plasma solution, ketone Ringer's solution, or nonresuscitation. After resuscitation, lung and liver samples were collected and evaluated for apoptosis by using ligation-mediated polymerase chain reaction.
Results: Nonresuscitated shock rats had significantly higher levels of apoptosis in lung and liver. Rats treated with normal saline solution, bicarbonate Ringer's solution, ketone Ringer's solution, and hypertonic saline solution had significantly lower levels of apoptosis in lung compared with nonresuscitated animals. Rats treated with bicarbonate Ringer's solution and ketone Ringer's solution had significantly lower levels of apoptosis in liver tissue when compared with nonresuscitated animals.
Conclusions: Cellular damage results from hemorrhagic shock. The use of resuscitation fluids decreases apoptosis during shock.
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| http://dx.doi.org/10.1016/j.amjsurg.2004.06.040 | DOI Listing |
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