Objective: This research explored the relationship between typical alcohol consumption and interest in participating in a brief alcohol intervention study and between typical consumption and actual participation in the study among students recruited to participate in an intervention study. We predicted a curvilinear relationship as a potential explanation for mixed findings from previous examinations of risk status and participation in alcohol intervention research. That is, we expected an inverted U-shaped relationship, with those at the lowest and highest ends of the drinking spectrum expressing the least interest in participation. We expected the same pattern to hold for likelihood of actual participation among study invitees.
Method: Self-reported typical consumption and interest in participating in an alcohol intervention study were assessed among 1,115 (59.7% female) college students. A subsample of these students (n = 377) who expressed interest and reported at least one heavy-drinking episode in the previous month were subsequently invited to participate in a brief intervention study.
Results: Drinkers were more likely than nondrinkers to report interest in participating, and there was a positive relationship between likelihood of expressing interest and typical consumption. However, the predicted quadratic relationship was evident with those at the lowest and highest ends of the drinking spectrum expressing the least interest in participation. The same pattern was also evident for actual participation among the heavy-drinking subsample invited to participate in the alcohol intervention study.
Conclusions: A nonlinear relationship may account for mixed findings regarding the relationship between risk status and participation in alcohol intervention studies. Results are interpreted in terms of psychological relevance and defensiveness. Findings highlight the need for added effort in recruiting, and/or alternative recruitment strategies for, those at highest risk.
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http://dx.doi.org/10.15288/jsa.2004.65.736 | DOI Listing |
J Integr Neurosci
January 2025
Neuroscience Department, University of Connecticut Health, School of Medicine, Institute for Systems Genomics, Farmington, CT 06030, USA.
Background: In neuroscience, Ca imaging is a prevalent technique used to infer neuronal electrical activity, often relying on optical signals recorded at low sampling rates (3 to 30 Hz) across multiple neurons simultaneously. This study investigated whether increasing the sampling rate preserves critical information that may be missed at slower acquisition speeds.
Methods: Primary neuronal cultures were prepared from the cortex of newborn pups.
Alcohol Clin Exp Res (Hoboken)
January 2025
Addiction Neuroscience, Department of Psychology and Indiana Alcohol Research Center, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Background: The loss of a job or relationship are a couple of examples of unexpected reward loss. Life events, such as these can induce negative emotional reactions (e.g.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, Italy.
Background/objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.
View Article and Find Full Text PDFPharmaceutics
January 2025
Institute of Chemistry Rosario, National Council for Scientific and Technical Research (IQUIR-CONICET), Rosario 2000, Argentina.
: Chagas disease is a neglected tropical disease caused by infection with the parasite . Benznidazole and nifurtimox are the only approved drugs for treating this condition, but their low aqueous solubility may lead to erratic bioavailability. This work aimed for the first time to formulate tablets of nifurtimox by hot melt extrusion coupled with 3D printing as a strategy to increase drug dissolution and the production of tablets with dosage on demand.
View Article and Find Full Text PDFPharmaceutics
December 2024
Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasília 70910-900, Brazil.
: This study aimed to evaluate the safety and efficacy of chitosan-based bioadhesive films for facilitating the topical delivery of curcumin in skin cancer treatment, addressing the pharmacokinetic limitations associated with oral administration. : The films, which incorporated curcumin, were formulated using varying proportions of chitosan, polyvinyl alcohol, Poloxamer 407, and propylene glycol. These films were assessed for stability, drug release, in vitro skin permeation, cell viability (with and without radiotherapy), and skin irritation.
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