Novel, porous, functionalised silica particles have been developed with controlled morphology, which promote covalent attachment of fluorescent dyes which can act as an optical barcode.
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Biomater Adv
January 2025
School of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, Ireland; Centre for Medical Engineering Research, Dublin City University, D09 NA55 Dublin, Ireland; Advanced Manufacturing Research Centre (I-Form), School of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, Ireland; School of Pharmacy, Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, United Kingdom; Biodesign Europe, Dublin City University, D09 NA55 Dublin, Ireland; Tissue, Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, D02 PN40 Dublin, Ireland; Advanced Processing Technology Research Centre, Dublin City University, D09 NA55 Dublin, Ireland; Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, D02 PN40 Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Trinity College Dublin, D02 PN40 Dublin, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, D02 PN40 Dublin, Ireland. Electronic address:
Magnesium (Mg) alloys have gained significant attention as a desirable choice of biodegradable implant for use in bone repair applications, largely owing to their unique material properties. More recently, Mg and Mg-based alloys have been used as load-bearing metallic scaffolds for bone tissue engineering applications, offering promising opportunities in the field. The mechanical properties and relative density of Mg-based alloys closely approximate those of natural human bone tissue, thereby mitigating the risk of stress-shielding effects.
View Article and Find Full Text PDFBr J Biomed Sci
December 2024
Faculty of Pharmacy, Arab International University, Daraa, Syria.
Mitochondria, known as the cell's powerhouse, play a critical role in energy production, cellular maintenance, and stemness regulation in non-cancerous cells. Despite their importance, using drug delivery systems to target the mitochondria presents significant challenges due to several barriers, including cellular uptake limitations, enzymatic degradation, and the mitochondrial membranes themselves. Additionally, barriers in the organs to be targetted, along with extracellular barriers formed by physiological processes such as the reticuloendothelial system, contribute to the rapid elimination of nanoparticles designed for mitochondrial-based drug delivery.
View Article and Find Full Text PDFBiomater Adv
February 2025
Advanced Organ bioengineering and Therapeutics, Department of Bioengineering Technologies, Faculty of Science and Technology, TechMed Centre, University of Twente, Drienerlolaan 5, 7522, NB, Enschede, the Netherlands.
Hybrid hydrogel networks were prepared from recombinant human-like collagen (rh-collagen) and poly(trimethylene carbonate-co-ε-caprolactone) (P (TMC-co-ε-CL)) to overcome the mechanical and bioactivity limitations associated with the respective individual networks. Both polymers were functionalised with methacrylic anhydride to yield photo-crosslinkable materials. Porous hybrid networks of different compositions were prepared by photo-crosslinking frozen mixtures of solutions of the functionalized polymers in acidified DMSO.
View Article and Find Full Text PDFChemistry
January 2025
School of Chemistry, The University of Melbourne, Parkville, Victoria, 3010, Australia.
The structural rigidity of tetrakis(4-pyridyl)porphyrin (TPyP) has been utilised to prepare a robust novel porous coordination polymer of composition Cd(TPyP)(sez) (TPyP=5,10,15,20-tetra(4-pyridyl)porphyrin, sez=1,2,5-benzoselenadiazole-5-carboxylate). The coordination polymer may be described as a hexagonal porphyrin nanotube (PNT) and has the potential to bind guest molecules through chalcogen bonding. Single crystal X-ray diffraction (SCXRD) data indicate an internal pore diameter ~9 Å which represents ~35 % of the crystal volume.
View Article and Find Full Text PDFBiomater Adv
January 2025
Process Engineering Division, CSIR-Central Electrochemical Research Institute, Karaikudi, Tamilnadu-630003, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address:
The present research aims to develop a Ca-Zn ion-incorporated surface functionalized 3D Ti cancellous bone scaffold for bone defect repair. The scaffold is designed to mimic human cancellous bone architecture through selective laser melting-based additive manufacturing. The chemical-based surface modification approach employed here created a Ca and Zn ions incorporated nano-porous surface layer with enhanced surface roughness and hydrophilicity.
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