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Intercellular, Linear Direct Immunofluorescence Staining Pattern of Sweat Glands and Hair Follicles may be Used as a Diagnostic Marker for Pemphigus Vulgaris in Cases where Epidermis is Missing.
Acta Derm Venereol
November 2024
Department of Dermatology and Allergy, LMU University Hospital, Munich, Germany; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Due to its rarity, it takes months for patients to be correctly diagnosed with pemphigus vulgaris. This delay can be exacerbated by factors such as incorrect biopsy site selection. When the epidermis detaches from the dermis, evaluating fluorescence patterns is impossible.
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- Allergy warnings for opioids in patient notes can restrict pain management options due to misconceptions about allergy severity.
- True IgE-mediated allergic reactions to opioids are rare, while milder reactions are often confused with anaphylaxis due to histamine release.
- A case involving a 28-year-old woman highlights how her mild reactions were misclassified as severe allergies, resulting in inappropriate allergy labels and delays in her surgery.
Factors affecting the use of salbutamol before hospital admission in children with asthma exacerbation.
Allergol Immunopathol (Madr)
November 2024
Division of Pediatric Allergy and Immunology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Background: Early home intervention for asthma exacerbation (AE) in children is associated with more favorable outcomes. Inhaled short-acting beta agonists (SABA) are the cornerstones of AE treatment.
Objectives: We aimed to determine what proportion of parents administered salbutamol to their children to treat asthma exacerbation at home, and the factors affecting the decision to administer the medication.
Timing of onset of intraoperative transfusion anaphylaxis: a literature review.
Nagoya J Med Sci
August 2024
Department of Anesthesiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Clinical diagnosis of intraoperative transfusion anaphylaxis using clinical symptoms is challenging and should be made carefully, as an incorrect clinical diagnosis can exacerbate surgical bleeding secondary to stopping a clinically indicated blood transfusion. The timing of onset of anaphylaxis to start of transfusion may be the key to correctly diagnosing intraoperative transfusion anaphylaxis clinically. However, the reliability of this measure remains unknown.
View Article and Find Full Text PDFOptimization of Basophil Activation Test in the Diagnosis and Qualification for Allergen-Specific Immunotherapy in Children with Respiratory Allergy to the House Dust Mite .
Int J Mol Sci
September 2024
Centre of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-503 Krakow, Poland.
Article Synopsis
- - The study optimized a basophil activation test (BAT) to improve detection of house dust mite (HDM) allergy in children with allergic respiratory diseases, involving 32 children (13 girls and 19 boys) aged 4-17, and a control group of 32 children with other types of allergies.
- - The BAT was conducted using various allergen concentrations to determine the best cut-off point for distinguishing between HDM-allergic and non-allergic individuals, finding that a cut-off of 9.76% activated basophils at 2.25 ng/mL yielded high sensitivity (90.6%) and perfect specificity (100%).
- - The results were highly consistent with other allergy testing methods, showing strong
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