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Salivary steroids in acute central serous chorioretinopathy.
Int Ophthalmol
January 2025
University of Pittsburgh, UPMC Eye Center, 203 Lothrop Street, Pittsburgh, PA, 15213, USA.
Purpose: To analyze levels of salivary steroids, including 17-OH-progesterone (17-OHP), androstenedione, dehydroepiandrosterone, cortisol, cortisone, progesterone, testosterone, and estradiol, in patients with acute central serous chorioretinopathy (CSCR) patients.
Methods: Acute CSCR patients and healthy individuals were included in this observational case-control study. Levels of salivary steroids were determined by high-performance liquid chromatography with tandem mass spectrometry detection.
Tissue microenvironments are extremely complex and heterogeneous. It is challenging to study metabolic interaction between the different cell types in a tissue with the techniques that are currently available. Here we describe a multimodal imaging pipeline that allows cell type identification and nanoscale tracing of stable isotope-labeled compounds.
View Article and Find Full Text PDFOxidation state of bioavailable dissolved organic matter influences bacterioplankton respiration and growth efficiency.
Commun Biol
January 2025
Marine Science Institute/Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA, USA.
Oxygen consumption by oceanic microbes can predict respiration (CO production) but requires an assumed respiratory quotient (RQ; ΔO/ΔCO). Measured apparent RQs (ARQs) can be impacted by various processes, including nitrification and changes in dissolved organic matter (DOM) composition, leading to discrepancies between ARQ and actual RQ. In DOM remineralization experiments conducted in the eastern North Atlantic Ocean, ARQs averaged 1.
View Article and Find Full Text PDFVariable peptide processing of a Conus (Asprella) neocostatus α-conotoxin generates bioactive toxiforms that are potent against distinct nicotinic acetylcholine receptor subtypes.
Biochem Pharmacol
January 2025
The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines. Electronic address:
Conusvenoms are composed of peptides that are commonly post-translationally modified, increasing their chemical diversity beyond what is encoded in the genome and enhancing their potency and selectivity. This study describes how PTMs alter an α-conotoxin's selectivity for specific nAChR subtypes. Venom from the cone snailConus(Asprella)neocostatuswas fractionated using high-performance liquid chromatography and tested using a behavioral intracranial mouse bioassay and a cholinergic calcium imaging assay using SH-SY5Y neuroblastoma cells.
View Article and Find Full Text PDFPlasma Alkylresorcinols is an objective biomarker for gluten intake in young children.
J Nutr
January 2025
Department of Clinical Sciences, Lund university, Malmö, Sweden; Department of Pediatrics, Skåne University Hospital, Malmö. Sweden. Electronic address:
Background: Alkylresorcinols are a well-established biomarker for whole grain intake. There is evidence suggesting that total plasma alkylresorcinol concentration may also be used as a biomarker for gluten intake in adults.
Objective: The aim of the study was to evaluate if total alkylresorcinol concentration is a valid biomarker for gluten intake in young children.
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