Objective: Basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) are involved in the pathogenesis of leiomyomas and influence angiogenesis, which is necessary for growth of leiomyomas. Gonadotropin-releasing hormone analogue (GnRH-a) treatment might modify the growth factor expression and the blood supply in myomas. We investigated the effects of GnRH-a treatment on some clinical parameters, on the immunohistochemical expression of bFGF, VEGF, and PDGF, and on the vasculature of leiomyomas.
Methods: Thirty-one women were treated with leuprolide acetate for 3 months; 55 untreated patients formed the control group. Hematologic parameters were assessed at the admission, after GnRH-a treatment, and after surgery. Uterine volume was evaluated by ultrasonography. The immunoexpression of bFGF, VEGF, and PDGF and of the endothelial markers CD34 and CD105, as well as the vascular pattern, were studied in leiomyomas, comparing treated and untreated patients.
Results: Hematologic parameters improved and uterine volumes decreased after GnRH-a treatment. The immunoexpression of bFGF, VEGF, and PDGF decreased in treated myomas, together with the total number of vessels and the angiogenetic vessels.
Conclusion: This study confirms the clinical response of uterine shrinkage after GnRH-a treatment. A pathogenetic role of bFGF, VEGF, and PDGF in myoma growth and vascularization is suggested. Finally, this study indirectly confirms the importance of the vasculature in leiomyoma growth.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jsgi.2004.10.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Impact of gonadotropin-releasing hormone agonist on pregnancy outcomes in frozen-thawed embryo transfer cycles for patients with recurrent implantation failure combined with chronic endometritis].
Zhonghua Yi Xue Za Zhi
January 2025
Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital/Beijing Maternal and Child Health Care Hospital Affiliated to Capital Medical University, Beijing100026, China.
To explore the impact of gonadotropin-releasing hormone agonist (GnRH-a) on the pregnancy outcomes in frozen-thawed embryo transfer cycles for patients with recurrent implantation failure (RIF) complicated by chronic endometriti (CE). A total of 138 patients with RIF combined with CE who underwent in vitro fertilization/intracytoplamic sperm injection treatment-embryo transfer in the Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 2020 to December 2023 were retrospectively included. According to the endometrial preparation protocol, they were divided into two groups: the pituitary downregulation group (=59) and the artificial cycle group (=79).
View Article and Find Full Text PDFHormonal induction and seasonal variation in male reproductive viability of the Southern Rocky Mountain boreal toad.
Anim Reprod Sci
December 2024
Conservation Biology Research Group, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
The Southern Rocky Mountain boreal toad (Anaxyrus boreas boreas) depends on both the rearing of wild-collected egg masses and a long-standing conservation breeding program (CBP), the latter of which heavily relies on assisted reproductive technologies (ARTs) to support wild populations. Achieving consistent reproductive success in the CBP, however, remains a significant challenge. Natural breeding has not led to a sustained increase in reproductive capacity, prompting the exploration of exogenous hormone treatments as an alternative strategy.
View Article and Find Full Text PDFCombining Medication With High-Intensity-Focused Ultrasound for Adenomyosis: A Network Meta-Analysis of Randomized Controlled Trials.
J Ultrasound Med
December 2024
Department of Gynecology, Zhejiang Hospital, Hangzhou, China.
This network meta-analysis aims to identify the best possible combination therapy for individuals suffering from adenomyosis. To identify pertinent research for the network meta-analysis, a comprehensive search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang, and VIP, spanning from their commencement to February 21, 2024. The study's focus was on evaluating outcomes including visual analog scale (VAS) scores for dysmenorrhea, measurements of uterine and lesion volumes, menstrual blood loss, and the rate of disease recurrence.
View Article and Find Full Text PDFGnRH antagonist impairs the process of embryo implantation by inhibiting motility of endometrial stromal cells through reducing c-kit expression.
Gynecol Endocrinol
December 2024
JXHC Key Laboratory of Fertility Preservation, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi Province, China.
Article Synopsis
- The study examines the impact of gonadotropin-releasing hormone antagonist (GnRH-ant) versus agonist (GnRH-a) protocols on clinical outcomes in IVF-ET cycles, involving over 18,000 patients from a specific hospital in China.
- Results indicate patients using GnRH-ant had significantly lower endometrial thickness and poorer outcomes, including lower implantation, pregnancy, and live birth rates, along with a higher rate of early miscarriage compared to the GnRH-a group.
- Additionally, experiments on human endometrial stromal cells revealed that GnRH-ant treatment led to decreased expression of proteins linked to cell migration and adhesion, suggesting these molecular changes may contribute to the observed negative clinical outcomes.
GnRH agonist pretreatment for frozen embryo transfer among women with polycystic ovary syndrome: a narrow systematic review and meta-analysis of randomized controlled trials.
Reprod Biol Endocrinol
October 2024
Women's Reproductive Health Research Key Laboratory of Zhejiang Province and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, People's Republic of China.
Article Synopsis
- Frozen embryo transfer (FET) is commonly used for women with polycystic ovary syndrome (PCOS) during IVF, but there's no clear agreement on the best way to prepare the endometrium for this process.
- The study aimed to investigate if using gonadotropin-releasing hormone agonist (GnRH-a) pretreatment before FET could lead to better clinical outcomes for women with PCOS.
- After reviewing multiple studies, only three randomized controlled trials (RCTs) involving 709 participants met the criteria, and the results showed no significant differences in clinical pregnancy rates, miscarriage rates, or live birth rates between the GnRH-a treatment group and the control group receiving an artificial cycle.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!