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Hacking the Immune Response to Solid Tumors: Harnessing the Anti-Cancer Capacities of Oncolytic Bacteria.
Pharmaceutics
July 2023
Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Oncolytic bacteria are a classification of bacteria with a natural ability to specifically target solid tumors and, in the process, stimulate a potent immune response. Currently, these include species of , , , / (Coley's Toxin), , , and . Advancements in techniques and methodology, including genetic engineering, create opportunities to "hijack" typical host-pathogen interactions and subsequently harness oncolytic capacities.
View Article and Find Full Text PDFNational Working Group on the RE-AIM Planning and Evaluation Framework: Goals, Resources, and Future Directions.
Front Public Health
January 2020
Adult and Child Consortium for Outcomes Research and Delivery Science Dissemination and Implementation Science Program and The Department of Family Medicine, School of Medicine, University of Colorado- Anschutz Medical Campus, Aurora, CO, United States.
The National Working Group on RE-AIM Planning and Evaluation Framework (herein Workgroup) was established in 2004 to support the application of the framework and advance dissemination and implementation science (D&I). Workgroup members developed and disseminated products and resources (and continue to do so) to advocate for consistent application of RE-AIM and allow for cross study comparisons. The purpose of this paper is to summarize key Workgroup activities, products, and services (e.
View Article and Find Full Text PDFValidity of sample sizes in publications of randomised controlled trials on the treatment of age-related macular degeneration: cross-sectional evaluation.
BMJ Open
October 2019
Institute for Medical Biometry and Epidemiology, University Witten Herdecke Faculty of Health, Witten, Germany.
Objective: The aim of this cross-sectional study was to examine the completeness and accuracy of the reporting of sample size calculations in randomised controlled trial (RCT) publications on the treatment of age-related macular degeneration (AMD).
Methods: A sample of 97 RCTs published between 2004 and 2014 was reviewed for the calculation of their sample size. It was examined whether a (complete) description of the sample size calculation was presented.
Hydralazine and nitrates in the treatment of heart failure with reduced ejection fraction.
ESC Heart Fail
August 2019
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Hydralazine and nitrate combination was the first treatment that showed improved survival of patients with heart failure with reduced left ventricular ejection fraction (HFREF) in the Vasodilator Heart Failure Trial (V-HeFT trial) in 1986. This showed a 34% reduction of mortality at 2 years of follow-up in patients with advanced heart failure (New York Heart Association Class IV). The angiotensin-converting enzyme inhibitor (ACEi), beta-blockers, mineralocorticoid receptor antagonists, and most recently sacubitril-valsartan have superseded the combination of hydralazine and nitrates.
View Article and Find Full Text PDFSurgical excision versus observation as initial management of desmoid tumors: A population based study.
Eur J Surg Oncol
April 2019
Department of Surgery, University of Calgary, Calgary, AB, Canada.
Synopsis: Desmoid tumors can be safely managed with watchful waiting, including either observation alone or tamoxifen/NSAIDs. Surgery at first presentation can be associated with significant treatment burden.
Background: Immediate surgery was historically recommended for desmoid tumors.
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