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Multiple Choroidal Neovascularizations in Choroidal Osteoma Treated with Anti-VEGF Injections: A 6-Year Follow-Up Case Report.
Retin Cases Brief Rep
March 2024
Dept. of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
Purpose: To report a case of multiple choroidal neovascularizations (CNVs) secondary to choroidal osteoma injected with a total of 13 anti-vascular endothelial growth factor (VEGF) drugs over a long-term follow up of 6-year period.
Methods: Case report.
Results: A 29-year-old female presented with a peripapillary choroidal osteoma in her left eye with the best-corrected visual acuity (BCVA) of 20/25.
A two-year longitudinal study of retinal vascular impairment in patients with amnestic mild cognitive impairment.
Front Aging Neurosci
November 2022
Reproductive and Odontostomatological Sciences, Department of Neurosciences, University of Naples "Federico II", Naples, Italy.
Objective: To evaluate the relation between retinal vascular impairment and cognitive decline in patients with amnestic mild cognitive impairment (aMCI) over time.
Methods: Spectral domain-optical coherence tomography (SD-OCT) and OCT angiography study was performed in aMCI patients over 2 years follow-up and compared to baseline.
Results: Thirty-eight eyes from 19 aMCI patients were evaluated.
Defining High-risk Retinoblastoma: A Multicenter Global Survey.
JAMA Ophthalmol
January 2022
Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Importance: High-risk histopathologic features of retinoblastoma are useful to assess the risk of systemic metastasis. In this era of globe salvage treatments for retinoblastoma, the definition of high-risk retinoblastoma is evolving.
Objective: To evaluate variations in the definition of high-risk histopathologic features for metastasis of retinoblastoma in different ocular oncology practices around the world.
Phenotype Analysis of Retinal Dystrophies in Light of the Underlying Genetic Defects: Application to Cone and Cone-Rod Dystrophies.
Int J Mol Sci
September 2019
Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, 17 rue Moreau, 75012 Paris, France.
Phenotypes observed in a large cohort of patients with cone and cone-rod dystrophies (COD/CORDs) are described based on multimodal retinal imaging features in order to help in analyzing massive next-generation sequencing data. Structural abnormalities of 58 subjects with molecular diagnosis of COD/CORDs were analyzed through specific retinal imaging including spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (BAF/IRAF). Findings were analyzed with the underlying genetic defects.
View Article and Find Full Text PDFArticle Synopsis
- This study aimed to assess the prevalence of high-risk histopathologic features (HRFs) in children with unilateral retinoblastoma post-enucleation and to explore the effectiveness of chemotherapy in preventing cancer recurrence.
- A total of 331 children were enrolled, with a central histopathology review revealing that 23% of those with HRFs had discordant results, highlighting the need for careful evaluation.
- The findings indicated high event-free survival rates for both patients treated with chemotherapy for HRFs (96%) and those observed without HRFs (99%), suggesting that proper histopathological assessment could influence treatment decisions and potentially improve outcomes for specific patient subgroups.
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