Objective: To study the effect on synthesis of nitric oxide in myocardium by local cryoablation and to investigate its mechanism.
Methods: Myocardium was cryoablated locally by a probe cooled to -60 degrees C and rewarmed by normal salt solution, nitric oxide and its synthesis enzyme were measured before and after cryoablation. L-arginine or methylene blue was added before and during cryoablation and the effect of these drugs on synthesis of nitric oxide was studied.
Results: Nitric oxide and its synthesis enzyme decreased after cryoablation; L-arginine preserved the synthesis of nitric oxide and methylene blue inhibited the synthesis of nitric oxide. However, nitric oxide in serum did not change.
Conclusion: Nitric oxide and its synthesis enzyme in myocardium decrease after cryoablation.
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| http://dx.doi.org/10.3785/j.issn.1008-9292.2005.01.016 | DOI Listing |
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