Objective: To investigate serum levels of mannose-binding lectin (MBL), a complement-like protein of collectin family, in patients with Behcet's disease (BD).
Methods: MBL levels were measured in sera of 130 patients with BD, 64 patients with recurrent oral ulcerations (ROU), and 105 healthy controls (HC) with ELISA.
Results: Patients with BD had significantly lower median serum MBL levels compared to HC (1857 vs 3136 ng/ml, p = 0.001). No significant difference was observed in median serum MBL levels between BD and ROU (2309 ng/ml, p = 0.252). Low MBL levels (= 500 ng/ml) were present in a higher proportion of BD patients compared to HC (29% vs 16%, p = 0.021). A severe disease course (total clinical severity score >/= 4) was more frequently observed in BD patients with very low serum MBL levels (= 100 ng/ml) (19% vs 6%, p = 0.046). When serum MBL levels were analyzed separately according to gender, the frequency of vascular disease was higher in men with very low serum MBL levels (80% vs 42%, p = 0.042).
Conclusions: MBL deficiency might contribute to the pathogenesis of BD and affect its clinical course.
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J Contemp Dent Pract
October 2024
Department of Crown and Bridge, Faculty of Dentistry, Al-Azhar University, Cairo, Egypt.
Aim: To assess hard as well as soft peri-implant tissues within cases having two lost adjacent anterior teeth treated through placing either two implants with two separate crowns or only an implant along with a crown with a cantilever, and evaluating the effect of polyetheretherketone (PEEK) restoration on cantilever design up to 18 months after functional loading.
Materials And Methods: Twenty-seven participants (15 males and 12 females; mean age, 38.6 years; range 20-50 years) with missing two adjacent anterior teeth were treated with implant system (Flotecno implant system, Italy).
J Prosthodont
January 2025
Division of Oral Surgery and Implantology, Department of Head and Neck, Institute of Clinical Dentistry, Oral Surgery and Implantology Unit, A. Gemelli University Hospital Foundation (IRCCS) Catholic University of the Sacred Heart, Rome, Italy.
Purpose: Screw-retained implant crowns are a common solution to rehabilitate single or multiple edentulous sites. Angulated screw channel (ASC) abutments have been developed as a new system of connection to correct the angulation of the implant and avoid a possible undesired emergence of the access hole. The purpose of this systematic review was to examine available literature related to the effects of ASC abutments in rehabilitating single implant crowns.
View Article and Find Full Text PDFInt Dent J
January 2025
Department of Dental Services, Emirates Health Services, Dubai, United Arab Emirates.
Objectives: The aim of this randomised controlled trial was to assess clinical, radiographic and patient reported outcomes of narrow versus standard diameter titanium zirconium (TiZr) implants supporting single crown restorations in posterior sites with limited bone width.
Materials And Methods: Participants requiring replacement of single missing posterior teeth with implant-supported crowns were randomly allocated into 2 treatment groups: narrow (3.3 mm) or standard (4.
Molecules
January 2025
Escuela Profesional de Farmacía y Bioquímica, Universidad Católica de Santa María, Urb. San José s/n, Umacollo, Arequipa 04000, Peru.
Epilepsy is a chronic neurological disorder that affects nearly 50 million people worldwide. Experimental evidence suggests that epileptic neurons are linked to the endocannabinoid system and that inhibition of the FAAH enzyme could have neuroprotective effects by increasing the levels of endogenous endocannabinoid anandamide. In this context, the use of macamides as therapeutic agents in neurological diseases has increased in recent years.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Translational and Clinical Research Program, Cancer Research Center (IBMCC, Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca), Cytometry Service, NUCLEUS, 37007 Salamanca, Spain.
The early immune kinetics after SARS-CoV-2 vaccination remain poorly understood, particularly among individuals with low-count monoclonal B-cell lymphocytosis (MBL). We investigated the cellular and humoral kinetics in the blood of 50 non-MBL healthy donors (HD) vs. 16 MBL subjects after SARS-CoV-2 vaccination, who were subclassified according to their history of previous exposure to SARS-CoV-2 into SARS-CoV-2 naïve and previously infected subjects.
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