AI Article Synopsis
- Post-transplant lymphoproliferative disorders (PTLD) are complications that can arise after solid organ transplants, often linked to Epstein-Barr virus (EBV).
- A 25-year-old renal transplant patient developed subcutaneous nodules three years post-transplant, which were biopsied and confirmed to be EBV-associated plasmocytoma, without signs of spreading beyond the skin.
- Treatment involved rituximab (an anti-CD20 therapy), which led to complete remission; while skin manifestations of EBV-related PTLD are rare, initial treatment typically involves reducing immunosuppression and monitoring.
Article Abstract
Introduction: Postransplant lymphoproliferative disorders are well known complications of solid organ transplant, usually associated with Epstein-Barr virus (EBV).
Observation: A 25 year old renal transplant patient presented with two subcutaneous nodules on the lower limb that appeared 3 years after a second renal transplantation. Biopsy of one nodule showed an EBV associated plasmocytoma located in the subcutaneous tissue. A complete systemic evaluation showed no evidence of extracutaneous involvement. The patient was treated with anti CD20 therapy (rituximab), and complete remission was achieved.
Discussion: Extranodular localisations of postransplant lymphoproliferative disorders are usually reported, but cutaneous localizations are rarely described. Histological presentation are various, but plasmocytoma-type is infrequent. Initial therapy of cutaneous EBV-associated postransplant lymphoproliferative disorders without extracutaneous involvement consists in reduction of the immunosuppression therapy and/or an antiviral treatment and prolonged surveillance. Treatment with monoclonal anti-CD20 antibodies (rituximab) is proposed.
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| http://dx.doi.org/10.1016/s0151-9638(04)93845-8 | DOI Listing |
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