PedvaxHIB is a pediatric vaccine that protects children from severe disease caused by the gram-negative bacterium Haemophilus influenzae type b (Hib). The vaccine is made by chemically conjugating Hib capsular polysaccharide to the outer membrane protein complex of Neisseria meningitidis. The protein-conjugated vaccine has proven to be extremely effective in preventing invasive Hib disease in infants and young children. This paper presents the nuclear magnetic resonance (NMR) methodology for the quantitative characterization of derivatized polysaccharide and its validation closely following ICH guidelines. The assay has been shown to be precise and accurate (relative standard deviation [RSD]
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http://dx.doi.org/10.1016/j.ab.2004.11.019 DOI Listing Publication Analysis
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School of Agriculture and Bioengineering, Heze University, Heze 274500, China. Electronic address:
Herin, the successful synthesis of a bis Schiff base (L) has been achieved using 2-hydroxy-1-naphthaldehyde and 1,3-diaminoguanidine as raw materials, which was further characterized by infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance hydrogen spectrum. Moreover, spectroscopic experiments demonstrated that the probe L showed good selectivity and visual detectability for Al. Its detection limit (DL) is 2.
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College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address:
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Laboratory of Nuclear Medicine (LIM43), Department of Radiology and Oncology, Faculdade de Medicina-FMUSP, Universidade de São Paulo, São Paulo 05403-911, SP, Brazil. Electronic address:
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Institute for Frontier Materials, Deakin University, Geelong VIC 3216, Australia. Electronic address:
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Comparison of DWI techniques in patients with epidermoid cyst: TGSE-BLADE DWI vs. SS-EPI DWI.
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Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Kyoto, 6068507, Japan.
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