[Kidneys--the place of synthesis, activity and degradation of endothelin-1].

Endothelin-1 (ET-1) belongs to the group of isopeptides which reveal vasoconstrictive property. The role of ET-1 in kidneys is still unclear, but results of many researches may indicate the importance of this peptide in physiological conditions and in renal pathology. Kidneys are the place of synthesis, activity and degradation of ET-1. Peptide produced in the renal cells (ex. in the glomerular, tubular and interstitial cells) acts as auto/paracrine substance. It was recognised that more that more than 70% of primary synthesised within the endothelium ET-1 is directed in the abluminal side. Peptide reveals many intrarenal properties such as regulation of renal hemodynamic and water-electrolyte balance which may influence on systemic function. Kidneys are also the place of ET-1 inactivating peptidase (metalloendopeptidase) formation. Many researches indicate the possible role of ET-1 in pathogenesis of many renal disorders such as: glomerulonephritis, acute and chronic renal failure and rejection of transplanted kidney Nephrotoxicity induced by cyclosporine maybe also partially provoked by ET-1.